Metal Complex Activation of Dioxygen

9408596加州大学瓦伦丁分校- 洛杉矶琼·S.瓦伦丁，化学系，加州-洛杉矶大学，是由无机，生物无机和有机化学计划的化学部的研究到金属络合物的活化双氧的支持。一个中心主题将是开发由含金属的加氧酶催化的生物反应的类似物。本论文将研究非卟啉金属配合物存在下的过氧化物反应，以期开发金属介导的烯烃环氧化和烷烃羟基化过程。然后将研究在α-酮戊二酸存在下有机底物的氧化。接下来将研究金属卟啉过氧配合物的类似反应。最后，这种化学物质将被转移到水溶液中。 在生物系统中，酶催化氧进入各种不同的物种。本研究是对设计用于模拟生物系统行为的模型化合物的系统研究。根据加氧酶的已知行为，将设计简单的系统来测试这些酶如何运作的想法。其结果将是更好地了解生命系统如何利用氧气，以及开发新的实验室和工业过程来激活氧气，以便将其纳入各种产品中。

9408596 Valentine Univ. of Calif. - Los Angeles Dr. Joan S. Valentine, Chemistry Department, University of California - Los Angeles, is supported by the Inorganic, Bioinorganic, and Organometallic Chemistry Program of the Chemistry Division for research into the activation of dioxygen by metal complexes. A central theme will be the development of analogs of biological reactions which are catalyzed by metal containing oxygenase enzymes. The reactions of peroxides in the presence of non-porphyrinic metal complexes will be investigated in hope of developing metal mediated olefin epoxidation and alkane hydroxylation processes. The oxygenation of organic substrates in the presence of alpha-ketoglutarate will then be investigated. Next similar reactions of metalloporphyrin peroxo complexes will be studied. Finally, this chemistry will be moved into aqueous solution. In biological systems, enzymes catalyze the incorporation of oxygen into a variety of different species. This study is a systematic investigation of model compounds which are designed to mimic the behavior of the biological systems. Based on the known behavior of oxygenase enzymes, simple systems will be designed to test ideas of how these enzymes operate. The result will be a better understanding of how living systems utilize oxygen and the development of new laboratory and industrial processes for activating oxygen so that it can be incorporated into various products.