Metal Complex Activation of Dioxygen

生物无机化学、无机化学和有机金属化学项目的这一奖项支持加州大学洛杉矶分校的琼·S·瓦伦丁博士的实验室研究。将进行的研究包括研究二氧化氧、超氧化物或过氧化氢与有机底物的有益和有毒的金属催化反应。原卟啉IX二甲酯的过氧铁络合物将被用作模型化合物，以阐明参与血红素含铁酶反应的中间体的性质。此外，还将研究铁-神经黑色素类似物和铜金属硫蛋白与抗坏血酸和碳水化合物的反应，以研究这些化合物在氧化损伤中的作用。最后，我们将用修饰的木兰素来模拟外加形成的氧化催化剂的毒性反应性。氧气及其代谢物的重要生物反应通常由金属酶催化。这些研究将促进我们对可能与退行性疾病有关的金属催化氧化反应的机制的理解。

This award in the Bioinorganic, Inorganic and Organometallic Chemistry Program supports research in the laboratories of Dr. Joan S. Valentine at the University of California Los Angeles. The research to be performed involves the study of both beneficial and toxic metal-catalyzed reactions of dioxygen, superoxide or peroxide with organic substrates. The ferric peroxo complex of protoporphyrin IX dimethyl ester will be used as a model compound to elucidate the nature of intermediates involved in the reactions of heme iron-containing enzymes. Additionally, the reactions of iron-neuromelanin analogs and copper metallothioneins with ascorbate and carbohydrates will be examined to investigate the role of such compounds in oxidative damage. Finally, modified stellacyanin will be used to model the toxic reactivity of adventitiously formed oxidation catalysts. Biologically important reactions of dioxygen and its metabolites are often catalyzed by metalloenzymes. The proposed studies will advance our understanding of the mechanisms of metal-catalyzed oxygenation reactions suspected to be involved in degenerative diseases.