Metal Complex Activation of Dioxygen

双氧的金属配合物活化

• 批准号: 9731057
• 负责人: Joan Valentine
• 金额: $ 45.25万
• 依托单位: University of California-Los Angeles
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-15 至 2002-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9731057&HistoricalAwards=false
• 关键词: Metal; Complex; Activation; Dioxygen

This award in the Bioinorganic, Inorganic and Organometallic Chemistry Program supports research in the laboratories of Dr. Joan S. Valentine at the University of California Los Angeles. The research to be performed involves the study of both beneficial and toxic metal-catalyzed reactions of dioxygen, superoxide or peroxide with organic substrates. The ferric peroxo complex of protoporphyrin IX dimethyl ester will be used as a model compound to elucidate the nature of intermediates involved in the reactions of heme iron-containing enzymes. Additionally, the reactions of iron-neuromelanin analogs and copper metallothioneins with ascorbate and carbohydrates will be examined to investigate the role of such compounds in oxidative damage. Finally, modified stellacyanin will be used to model the toxic reactivity of adventitiously formed oxidation catalysts. Biologically important reactions of dioxygen and its metabolites are often catalyzed by metalloenzymes. The proposed studies will advance our understanding of the mechanisms of metal-catalyzed oxygenation reactions suspected to be involved in degenerative diseases.

生物无机，无机和有机化学奖 该计划支持琼·S博士实验室的研究。瓦伦丁在 加州洛杉矶大学。拟进行的研究 涉及有益和有毒的金属催化反应的研究 分子氧、超氧化物或过氧化物与有机底物的反应。 铁 原卟啉IX二甲酯的过氧络合物将被用作 模型化合物，以阐明参与的中间体的性质 血红素含铁酶的反应。此外，反应 铁-神经黑色素类似物和铜金属硫蛋白与抗坏血酸和 碳水化合物将被检查，以研究这些化合物的作用 在氧化损伤中。最后，修饰的星花青苷将用于建模 偶然形成的氧化催化剂的毒性反应性。 分子氧及其代谢产物的生物学重要反应是 通常由金属酶催化。建议的研究将促进我们的 理解金属催化氧化反应的机理 怀疑与退行性疾病有关