Membrane-Based Process for the Synthesis of Chiral Pyrethroids

许多杀虫剂都是手性的--也就是说，它们的化学结构 作为一对“手”对映体存在。 一般来说，只有一个 该对对映异构体表现出所需的生物活性。 尽管有越来越多的证据表明，关键的杀虫剂应该 作为单一对映体开发和销售，超过90%的 合成手性农药作为外消旋混合物销售， 其含有两种对映体。 主要原因是， 的成本高，技术难度大， 对映异构体纯的手性中间体需要制备 手性农药 这个项目的目标是开发一个简单的，成本- 制备对映体纯（S）-m- 苯氧基苯甲醛氰醇，一种重要的手性中间体 用于合成拟除虫菊酯杀虫剂--商业上 一类重要的高效杀虫剂。 在第一阶段，我们 证明了我们的技术和经济可行性 基于双膜酶反应器的方法 过程 在这个第二阶段计划中，我们计划描述和 优化流程，通过建设和运营 实验室规模的单位，产生必要的数据，商业化 与我们可能的第三阶段赞助商，一个主要的 间苯氧基苯甲醛氰醇的生产商。

Many pesticides are chiral--that is, their chemical structures exist as a pair of "hand" enantiomers. Generally, only one of the pair of enantiomers exhibits the desired biological activity. Despite mounting evidence that critical pesticides should be developed and marketed as single enantiomers, more than 90% of the synthetic chiral pesticides are marketed as racemic mixtures, which contain both enantiomers. The principal reason is because of the high cost and technical difficulty of preparing the enantiomerically pure chiral intermediates needed to prepare the chiral pesticide. The goal of this program is to develop a simple, cost- effective process to prepare enantiomerically pure (s)-m- phenoxybenzaldehyde cyanohydrin, an important chiral intermediate used in the synthesis of pyrethroid insecticides--a commercially important class of highly effective insecticides. In Phase I, we demonstrated the technical and economic feasibility of our approach, which is based on dual-membranes enzyme-reactor process. In this Phase II program, we plan to characterize and optimize the process and, through construction and operation of a bench-scale unit, generate the data necessary to commercialize the process with our probable Phase III sponsor, a major manufacturer of m-phenoxybenzaldehyde cyanohydrin.