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The Cerebral Cortex as a Target of Estrogen

大脑皮层作为雌激素的靶点

基本信息

批准号：
9109375
负责人：
C. Dominique Toran-Allerand
金额：
$ 21.63万
依托单位：
Columbia University
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
1992
资助国家：
美国
起止时间：
1992-06-01 至 1996-02-29
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=9109375&HistoricalAwards=false
关键词：
Cerebral Cortex Target Estrogen

项目摘要

Appropriate development and maintenance of the connections and metabolism of neurons are necessary requisites to all functions of the nervous system, including the processes of learning and memory and other cognitive abilities. Knowledge of the substances that regulate these processes in mature neurons and during development is limited. However, two classes that have been implicated in the development, survival, and regeneration of neurons in cerebral cortex, the brain region involved cognitive functions, are the steroid hormone, estradiol, and the locally-synthesized growth- and survival-promoting protein, nerve growth factor (NGF). Indeed, Dr. Toran-Allerand has demonstrated that neurons of cerebral cortex contain receptors for both estrogen and NGF. She will now investigate in parallel the developmental history of the co-expressed estrogen and NGF receptor systems in vivo and analyze the cellular and molecular consequences of estrogen/NGF interactions in vitro. The results of this work will provide insights into those factors that may be of importance to the development of brain regions which underlie cognitive functions. Moreover, the basic information gained from this work may ultimately provide a biological rationale for clinical investigations into possible therapeutic approaches involving both estrogen and NGF in Alzheimer's disease and related disorders of cognition.

神经元的连接和代谢的适当发育和维持是神经系统所有功能的必要条件，包括学习、记忆和其他认知能力的过程。在成熟神经元和发育过程中调节这些过程的物质的知识是有限的。然而，有两类激素与大脑皮层（涉及认知功能的大脑区域）神经元的发育、存活和再生有关，即类固醇激素雌二醇和局部合成的促进生长和存活的蛋白质神经生长因子（NGF）。事实上，Toran-Allerand博士已经证明，大脑皮层的神经元含有雌激素和神经生长因子的受体。她现在将并行研究体内雌激素和NGF受体系统共表达的发育历史，并分析体外雌激素/NGF相互作用的细胞和分子后果。这项工作的结果将为那些可能对构成认知功能的大脑区域的发展具有重要意义的因素提供见解。此外，从这项工作中获得的基本信息可能最终为临床研究涉及雌激素和NGF治疗阿尔茨海默病和相关认知障碍的可能治疗方法提供生物学依据。