Research on serotonergic neurons projecting to the prefrontal cortex as a target of drug development against psychiatric disorders

对投射到前额皮质的血清素能神经元作为精神疾病药物开发目标的研究

• 批准号: 22590249
• 负责人: SUZUKI Hidenori
• 金额: $ 2.91万
• 依托单位: Nippon Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590249/
• 关键词: 5-HT 受容体; 中脳背側縫線核; セロトニン神経細胞; GABA 作動性神経細胞; 不安障害; 選択的セロトニン再取り込み阻害薬; 前頭前野; 海馬; ストレス; 不安様行動; 5-HT2A/2C受容体; 5-HT1A受容体; GABA作動性神経細胞; GAD67-GFPマウス; セロトニン神経系; 5-HT1_Aセロトニン受容体作働薬; 脳由来神経栄養因子; D_1ドパミン受容体; 5-HT_4セロトニン受容体; 5-HT_<1A>セロトニン受容体

In rats with late-emerging anxiety symptoms, decreased expression of 5-HT_1A receptor (5-HT_1A-R) mRNA was observed in the medial prefrontal cortex (mPFC) before emerging of the abnormal behaviors. Early therapeutic interventions with serotonergic drugs prevented the anxiety symptoms in the rats in association with normalization of5-HT1A-R mRNA expression. In the dorsal raphe nucleus innervating mPFC, electrophysiology revealed that various current responses were elicited by serotonin in GABAergic cells viamultiple 5-HT receptor subtypes, including 5-HT_1A, 5-HT_2A/2C and 5-HT_7.

在出现迟发性焦虑症状的大鼠中，在出现异常行为之前，内侧前额叶皮质(MPFC)中5-HT1A受体(5-HT1A-R)的表达降低。5-羟色胺能药物的早期治疗干预预防了大鼠的焦虑症状，并与5-HT1A-R基因表达正常化有关。在支配mPFC的中缝背核，电生理显示5-羟色胺可在GABA能细胞内引起多种5-羟色胺受体亚型的电流反应，包括5-羟色胺1A、5-羟色胺2A/2C和5-羟色胺7。

项目成果

Modulatory effects of serotonin on glutamatergic synaptic transmission and long-term depression in the deep cerebellar nuclei

• DOI: 10.1016/j.neuroscience.2010.10.037
• 发表时间: 2011-01
• 期刊: Neuroscience
• 影响因子: 3.3
• 作者: M. Murano;F. Saitow;H. Suzuki

Behavioral destabilization induced by the selective serotonin reuptake inhibitor fluoxetine.

• DOI: 10.1186/1756-6606-4-12
• 发表时间: 2011-03-16
• 期刊: Molecular brain
• 影响因子: 3.6
• 作者: Kobayashi K;Ikeda Y;Suzuki H
• 通讯作者: Suzuki H

マウス背側縫線核におけるニューロンの電気生理学的特性

小鼠中缝背核神经元的电生理特性

• 发表时间: 2013
• 作者: Nambu A;Chiken S;Shashidharan P;Nishibayashi H;Ogura M;Kakishita K;Tanaka S;Tachibana Y;Kita H;Itakura T;吉田正俊;牛腸義宏ほか
• 通讯作者: 牛腸義宏ほか

セロトニン5-HT4受容体欠損マウスにおける恐怖条件付けのメス特異的な亢進

女性特异性增强血清素 5-HT4 受体缺陷小鼠的恐惧条件反射

• 发表时间: 2011
• 作者: Takao;K.;小林克典
• 通讯作者: 小林克典

Effects of early intervention with fluoxetine on anxiety-related behaviors induced in prenatally glucocorticoid exposed rats

氟西汀早期干预对产前糖皮质激素暴露大鼠焦虑相关行为的影响

• 发表时间: 2010
• 作者: Nagano M;Liu M;Ozawa H;Suzuki H.
• 通讯作者: Suzuki H.