Metal Facilitated Transformations of Cyclopropane Derivatives

金属促进环丙烷衍生物的转化

• 批准号: 9109677
• 负责人: Paul Jennings
• 金额: $ 13.1万
• 依托单位: Montana State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-07-01 至 1993-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9109677&HistoricalAwards=false
• 关键词: Metal; Facilitated; Transformations; Cyclopropane; Derivatives

With support from the Organic Dynamics Program, Dr. Jennings will attempt to provide a mechanistic rationale to account for the observed course of a highly stereo- and regioselective platinum-mediated organic transformation and to further explore its potential utility in organic synthesis. In addition, Dr. Jennings plans to develop new catalytic transformations of olefinic substrates which will proceed with high degrees of regio- and stereoselectivity to afford useful products. %%% Metal-facilitated organic transformations have evolved into a significant subdiscipline of organic/organometallic chemistry. Dr. Jennings will utilize organoplatinum compounds in a unique manner that is expected to render them useful as catalysts that are capable of promoting synthetically useful cyclopropane transformations. In addition to adding significantly to our mechanistic understanding of metal-facilitated organic transformations, Dr. Jennings' studies are expected to lead to new methodology that can be used to synthesize interesting natural products.

在有机动力学项目的支持下，詹宁斯博士将尝试提供一个机制基础，以解释观察到的高度立体和区域选择性的铂介导的有机转化过程，并进一步探索其在有机合成中的潜在用途。此外，詹宁斯博士计划开发新的烯烃底物的催化转化，这种转化将具有高度的区域和立体选择性，以提供有用的产品。金属促进的有机转化已发展成为有机/有机金属化学的一个重要分支学科。詹宁斯博士将以一种独特的方式利用有机铂化合物，有望使它们成为催化剂，能够促进合成有用的环丙烷转化。詹宁斯博士的研究不仅大大加深了我们对金属促进的有机转化的机械理解，还有望带来可用于合成有趣的天然产品的新方法。