Studies of Erythrocyte-Endothelial Interactions in Sickle Cell Disease by Image Analyis

通过图像分析研究镰状细胞病中的红细胞-内皮相互作用

• 批准号: 9110461
• 负责人: Gilda Barabino
• 金额: $ 21.49万
• 依托单位: Northeastern University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-06-01 至 1995-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9110461&HistoricalAwards=false
• 关键词: Studies; Erythrocyte; Endothelial; Interactions; Sickle

This study is to examine the abnormal adhesive interactions between sickle blood cells and the endothelial cells of arterial wall under physiological flow conditions. A well characterized model system using a flow chamber will be utilized to study this interaction under well quantitated conditions. The study will be aided by the use of digital processing of video-taped images showing the interactions between the red blood cells and endothelial cells deposited on glass slides. Utilizing engineering technology in a novel way, this study will contribute to our understanding of the pathophysiology of sickle cell disease. The grant will also allow the professional development of an exemplary role model for underrepresented minorities.

本研究旨在探讨 异常粘附相互作用 镰状血细胞和 动脉壁内皮细胞 在生理流量下 条件 良好表征的 使用流动室的模型系统 将被用来研究这个问题 良好定量下的相互作用 条件 本研究将 借助数字化 录像图像处理 展示了 红细胞和内皮细胞 细胞沉积在载玻片上。 利用工程技术， 一种新的方式，这项研究将 有助于我们理解 镰状细胞病的病理生理学 疾病 该补助金还将允许 一个人的专业发展 模范榜样， 代表性不足的少数民族。