Grant for Exploratory Research: Laser NMR Spectroscopy

沃伦教授得到了一笔探索性研究的资助。 研究从实验物理化学计划， 开发方法，利用新的 观察到的现象，其中照射样品与 圆偏振光引起NMR中的频移 手性分子的光谱线。 因为每个核磁共振核， 取决于其相对于发色团的位置， 经历不同的符号和幅度的频移， 这种现象有可能能够区分 在位于靠近发色团的质子中， 拥挤的频谱。 消除所有信号是可能的 大多数是非手性分子，为了观察 少数手性物种，通过采取差光谱， 左旋圆偏振光与右旋圆偏振光。 由于许多 重要的分子是光学活性的，这种现象可能 有非常强大的应用。有可能 将这种技术结合到多维核磁共振中 复杂系统的光谱学，与激光在一个 维度 %%% 这个探索性的研究项目将利用公正的 发现了对核磁共振（NMR）的影响 靠近发色团的细胞核信号 具有手性的分子的基团（光学活性） 在用圆偏振可见光照射时， 激光。 完全消除所有信号是可能的， 所有其他非光学活性分子的NMR光谱 在样品中。 如果成功的话，这项技术将成为 对样品的NMR光谱有很大的影响， 生物分子

Professor Warren is supported by a grant for exploratory research from the Experimental Physical Chemistry Program to develop the methods that will take advantage of a newly observed phenomenon in which irradiation of samples with circularly polarized light causes frequency shifts in the NMR spectral lines of a chiral molecule. Since each NMR nucleus, depending on its location relative to the chromophore, will experience a different sign and magnitude of frequency shift, this phenomenon has the potential of being able to distinguish among the protons located close to the chromophore in a congested spectrum. It is possible to eliminate all signals from achiral molecules in the majority, in order to observe minority chiral species by taking a difference spectrum for left vs. right circularly polarized light. Since many important molecules are optically active, this phenomenon could have very powerful applications. There are possibilities of incorporating this technique into multidimensional NMR spectroscopy of complex systems, with the laser on in one dimension. %%% This exploratory research project will make use of the just discovered effect on the nuclear magnetic resonance (NMR) signals of nuclei that are located close to the chromophore group of a molecule possessing handedness (optically active) upon irradiation with circularly polarized visible light using a laser. It is possible to eliminate entirely all signals in the NMR spectrum from all other non-optically active molecules in the sample. If successful, this technique could have a great impact on the NMR spectroscopy of samples containing biological molecules.