Dynamics and Characterization of Long-Lived Hyperpolarized Molecules in Magnetic Resonance

磁共振中长寿命超极化分子的动力学和表征

• 批准号: 1058727
• 负责人: Warren Warren
• 金额: $ 60万
• 依托单位: Duke University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-02-15 至 2015-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1058727&HistoricalAwards=false
• 关键词: Dynamics; Characterization; Long; Lived; Hyperpolarized

In this project funded by the Chemical Structure, Dynamics and Mechanisms Program of the Chemistry Division, Professor Warren S. Warren of Duke University will determine experimentally and understand theoretically the fundamental limits of singlet spin relaxation times in structured materials. This involves synthesis of optimized, next-generation magnetic resonance agents targeted to measure specific metabolic and enzymatic processes and clarify questions on molecular dynamics. The goal here is to use quantum mechanics to design molecules which can preserve hyperpolarization far longer than the few seconds available by traditional methods, thus broadening their utility. The intellectual merit of the proposed activity comes from the integration of seemingly disparate fields (decoherence reduction in quantum computing; chemical physics, synthetic organic chemistry, molecular biology) to address fundamental questions about spin dynamics. Broader impacts include the potential this work has to revolutionize materials imaging and in vivo magnetic resonance spectroscopy. This work will dramatically improve the utility of newly developed methods which turn normally invisible molecules into nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) "light bulbs" and thus elucidate chemical dynamics. Professor Warren and his students will create compounds which act as "light bulbs" far longer than the seconds currently available, thus permitting studies of slower processes such as biochemical reactions. The long term impact in both fields could be profound; for example, almost all MRI scans are only of water, and this could permit scans using molecules that detect specific disease pathways.

本研究由化学系化学结构、动力学和机理研究计划资助，研究人员Warren S。杜克大学的沃伦将从实验上确定并从理论上理解结构材料中单重态自旋弛豫时间的基本极限。 这涉及到优化的下一代磁共振试剂的合成，目标是测量特定的代谢和酶促过程，并澄清分子动力学问题。 这里的目标是使用量子力学来设计分子，这些分子可以保持超极化的时间远远超过传统方法的几秒钟，从而扩大它们的实用性。 拟议活动的智力价值来自于整合看似不同的领域（量子计算中的退相干减少;化学物理学，合成有机化学，分子生物学），以解决有关自旋动力学的基本问题。更广泛的影响包括这项工作有可能彻底改变材料成像和体内磁共振光谱。 这项工作将大大提高新开发的方法的实用性，这些方法将通常不可见的分子变成核磁共振（NMR）和磁共振成像（MRI）“灯泡”，从而阐明化学动力学。 沃伦教授和他的学生们将创造出一种化合物，这种化合物作为“灯泡”的作用时间远远超过目前可用的秒数，从而可以研究诸如生化反应等较慢的过程。 这两个领域的长期影响可能是深远的;例如，几乎所有的MRI扫描都只针对水，这可能允许使用检测特定疾病途径的分子进行扫描。