Small Grants for Exploratory Research: Laser Atomization of Medical Solutions Used in Aerosal Therapy

这是SGER关于液体表面激光雾化的建议，具有潜在的医疗应用。P.I.将研究从气雾剂治疗中使用的药物溶液中产生尺寸分布受控(在1到5微米之间)的气雾剂的可行性，而不会影响溶液的化学完整性。初步研究表明，颗粒应在1至2微米的范围内，以最大限度地发挥气雾剂治疗的效果。如果气雾剂通过通风回路给药，实际上只有1%到3%的原量药物到达目标位置。长期目标是通过使用光纤输送系统将药物直接雾化在肺部的大呼吸道内。这项拟议的技术是一项美国专利权利要求的对象，该专利名为“形成精细粒子”。该项目将确定拟议概念的有效性，这可能在医学领域产生长期影响，并可能导致在产生超细气溶胶领域的基本发现。

This is a SGER proposal on laser atomization from a liquid surface, with potential medical applications. The P.I. will investigate the feasibility of generating aerosols with controlled size distribution (between 1 and 5 microns) from drug solutions used in aerosol therapy, without compromising the chemical integrity of the solution. Preliminary studies indicate that the particles should be in the 1 to 2 micron size range to maximize the effectiveness of aerosol therapy. If the aerosol is administered through a ventilation circuit, only 1 to 3% of the original volume of medication actually reaches the target site. The long term objective is atomization of drugs directly within the large airways of lungs through the use of a fiber optic delivery system. The proposed technique is the object of a U.S. patent claim "Forming Fine Particles". The project will establish the validity of the proposed concept, which may have long-reaching implications in medical field and may lead to fundamental findings in the area of generating ultrafine aerosols.