US-Czechoslovak Research on Oriented Protein Immobilization:Chemical and Biological Approaches

贝勒大学的威廉·H·斯库滕博士和捷克斯洛伐克科学院研究所的雅罗斯拉瓦·特科娃和米兰·贝内斯博士开展的这项美国-捷克斯洛伐克研究项目的主要目标是调查以目视定向和/或定向方式固定各种蛋白质。美国和捷克斯洛伐克的研究人员采取的方法虽然截然不同，但却是互补的。美国研究人员一直试图利用基质、激活剂和酶本身的化学特征来创造一种广泛和一般类型的取向。捷克斯洛伐克的研究人员一直在使用固定化蛋白质或其他生物分子与待固定化蛋白质之间的生物相互作用。预期结果将促进两个小组之间的技术方法交流。这个生物化学项目通过使美国和东欧的顶尖专家能够将互补的人才结合在一起，并在相互感兴趣和能力很强的领域汇集资源，从而实现了促进科学知识的计划目标。

The primary objective of this U.S.-Czechoslovakia research project between Dr. William H. Scouten of Baylor University and Drs. Jaroslava Turkova and Milan Benes of institutes in the Czechoslovak Academy of Sciences is to investigate the immobilization of various proteins in a sight- directed and/or oriented fashion. The approaches taken by the American and Czechoslovak researchers, while distinct, are complementary. The American researchers have been attempting to create a broad and general type of orientation using chemical features of the matrix, the activating agent, and of the enzyme itself. The Czechoslovak researchers have been using biological interactions between an immobilized protein, or other biomolecule, and the protein to be immobilized. Results are expected to facilitate the exchange of technical methods between the groups. This project in biochemistry fulfills the program objective of advancing scientific knowledge by enabling leading experts in the United States and Eastern Europe to combine complementary talents and pool resources in areas of strong mutual interest and competence.