Thermodynamic and NMR Studies of E. coli Cytoplasm

在实验物理化学的支持下， 生物化学和分子结构程序，教授记录 将使用核磁共振来测量离子 浓度在完整的，活细胞受到渗透压 应力统计力学理论将用于 解释这些数据，并获得分子水平的模型， 热力学非理想性在功能细胞过程中的作用。 %%% Record教授将使用现代的非侵入式光谱技术 技术来监测重要离子的浓度， 完整的活细胞他将利用热力学理论， 这些数据，以发展的作用， 浓缩的溶液来决定细胞的功能。这 是一个很好的例子， 实验物理化学的重要性，复杂性 系统.

With support from the Experimental Physical Chemistry and Biochemistry and Molecular Structure Programs, Professor Record will use Nuclear Magnetic Resonance to measure ion concentrations in intact, living cells subject to osmotic stress. Statistical mechanical theories will be used to interpret these data and obtain a molecular level model for the role of thermodynamic nonideality in functional cell processes. %%% Professor Record will use modern, non-invasive spectroscopic techniques to monitor concentrations of important ions in intact, living cells. He will use thermodynamic theories with these data to develop a general understanding of the role of concentrated solutions in determining how cells function. This is a beautiful example of how to apply theoretical and experimental physical chemistry to important, complicated systems.