Thermodynamic and NMR Studies of E. coli Cytoplasm

在实验物理化学、生物化学和分子结构项目的支持下，Record教授将使用核磁共振测量受渗透胁迫的完整活细胞中的离子浓度。统计力学理论将用于解释这些数据，并获得一个分子水平模型的作用，热力学非理想的功能细胞过程。Record教授将使用现代的非侵入性光谱技术来监测完整活细胞中重要离子的浓度。他将利用热力学理论和这些数据，对浓缩溶液在决定细胞功能方面的作用有一个大致的了解。这是如何将理论和实验物理化学应用于重要而复杂的系统的一个很好的例子。

With support from the Experimental Physical Chemistry and Biochemistry and Molecular Structure Programs, Professor Record will use Nuclear Magnetic Resonance to measure ion concentrations in intact, living cells subject to osmotic stress. Statistical mechanical theories will be used to interpret these data and obtain a molecular level model for the role of thermodynamic nonideality in functional cell processes. %%% Professor Record will use modern, non-invasive spectroscopic techniques to monitor concentrations of important ions in intact, living cells. He will use thermodynamic theories with these data to develop a general understanding of the role of concentrated solutions in determining how cells function. This is a beautiful example of how to apply theoretical and experimental physical chemistry to important, complicated systems.