Acquisition of an Elemental Analyzer

化学研究仪器项目的这一奖项将帮助斯克里普斯诊所和研究基金会获得一台元素分析仪。该仪器将为化学系的研究人员提供基本的分析支持，包括参与研究项目的合成、生物有机和分析化学家，这些研究项目包括：复杂天然产物的合成，复杂有机和有机金属化合物的设计和合成，催化抗体，酶抑制剂的设计和合成，多肽、寡核苷酸及其类似物的合成，酶的分离、天然酶的修饰、人工酶的合成以及新的合成技术的发展。斯克里普斯(免疫学、分子和实验医学、分子生物学和神经药理学)和斯克里普斯以外的部门也将通过已经建立的质谱学用户设施使用这一设施。元素分析结合质谱学、核磁共振和X射线结晶学可以提供足够的信息，从而能够明确地确定分子结构。这项技术的显著特点包括能够一致和快速地为几乎所有种类的有机材料提供明确的成分数据，而与样品的物理特性(即晶体大小和分子离子的稳定性)无关。此外，元素分析是唯一可以评估样品纯度的方法。元素分析提供的独特和基本的信息促进了化学和生物科学的研究。这在结构化学、合成化学和生物有机化学中尤其如此。

This award from the Chemistry Research Instrumentation Program will help the Scripps Clinic and Research Foundation acquire an Elemental Analyzer. This instrument will provide fundamental analytical support for researchers in the Department of Chemistry including synthetic, bioorganic and analytical chemists involved in research projects that include: synthesis of complex natural products, design and synthesis of complex organic and organometallic compounds, catalytic antibodies, design and synthesis of enzyme inhibitors, synthesis of peptides, oligonucleotides and their analogs, isolation of enzymes, modification of natural enzymes, synthesis of artifical enzymes, and the development of new synthetic technology. Departments at Scripps (Immunology, Molecular and Experimental Medicine, Molecular Biology and Neuropharmacology) and outside of Scripps will also have access to this facility through an already established mass spectrometry user facility. %%% Elemental analysis combined with mass spectrometry, nuclear magnetic resonance and x-ray crystallography can provide sufficient information to allow for the unequivocal determination of molecular structure. The distinctive characteristics of this technology include its ability to provide unambiguous compositional data consistently and quickly for virtually all of the numerous classes of organic materials, independent of the physical characteristics of a sample (i.e., crystal size and the stability of the molecular ion). In addition, elemental analysis is the only method that can evaluate sample purity. The unique and fundamental information provided by elemental analysis facilitates research in the chemical and biological sciences. This is particularly true in structural, synthetic and bioorganic chemistry.