Acquisition of an Elemental Analyzer

化学研究仪器计划的这个奖项 将帮助斯克里普斯诊所和研究基金会获得 元素分析仪。 该工具将提供基本的 为化学系研究人员提供分析支持 包括合成、生物有机和分析化学家 在研究项目，其中包括：合成复杂的自然 产品、设计和合成复杂的有机和 有机金属化合物，催化抗体，设计和 酶抑制剂的合成，肽的合成， 寡核苷酸及其类似物，酶的分离， 天然酶的修饰，人工酶的合成， 以及新合成技术的开发。 部门 斯克里普斯（免疫学，分子和实验医学， 分子生物学和神经药理学）和斯克里普斯以外 也将通过一个已经存在的 建立质谱用户设施。 %%% 元素分析结合质谱法，核 磁共振和X射线晶体学可以提供 有足够的信息可以明确确定 分子结构。 这一独特的特征 技术包括其提供明确 一致和快速地为几乎所有的 许多种类的有机材料，独立于 样品的物理特性（即，晶体尺寸和 分子离子的稳定性）。 此外，元素分析 是评价样品纯度的唯一方法。 独特的 元素分析提供的基本信息 促进了化学和生物科学的研究。 在结构、合成和生物有机方面尤其如此 化学.

This award from the Chemistry Research Instrumentation Program will help the Scripps Clinic and Research Foundation acquire an Elemental Analyzer. This instrument will provide fundamental analytical support for researchers in the Department of Chemistry including synthetic, bioorganic and analytical chemists involved in research projects that include: synthesis of complex natural products, design and synthesis of complex organic and organometallic compounds, catalytic antibodies, design and synthesis of enzyme inhibitors, synthesis of peptides, oligonucleotides and their analogs, isolation of enzymes, modification of natural enzymes, synthesis of artifical enzymes, and the development of new synthetic technology. Departments at Scripps (Immunology, Molecular and Experimental Medicine, Molecular Biology and Neuropharmacology) and outside of Scripps will also have access to this facility through an already established mass spectrometry user facility. %%% Elemental analysis combined with mass spectrometry, nuclear magnetic resonance and x-ray crystallography can provide sufficient information to allow for the unequivocal determination of molecular structure. The distinctive characteristics of this technology include its ability to provide unambiguous compositional data consistently and quickly for virtually all of the numerous classes of organic materials, independent of the physical characteristics of a sample (i.e., crystal size and the stability of the molecular ion). In addition, elemental analysis is the only method that can evaluate sample purity. The unique and fundamental information provided by elemental analysis facilitates research in the chemical and biological sciences. This is particularly true in structural, synthetic and bioorganic chemistry.