EAGER: ASYMMETRIC CHLORINATION
EAGER:不对称氯化
基本信息
- 批准号:1342529
- 负责人:
- 金额:$ 14.99万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-05-15 至 2014-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
With this EAGER award, the Chemical Synthesis Program is funding Professor K.C. Nicolaou of Rice University to attempt to develop the first viable catalytic, asymmetric olefin dichlorination. Though clearly of high risk, success across any of the olefin classes to be investigated in this study, would represent high reward, with a likely impact on natural product, medicinal, process and combinatorial chemistry endeavors. The Nicolaou group will explore complementary organocatalytic and organometallic avenues toward the title transformation, with cinchona alkaloids among the chiral scaffolds expected to impart asymmetry, and with both relatively non-polarized alkenes and polarized alkenes of the alpha,beta-unsaturated carbonyl variety to be explored.If successful, a catalytic asymmetric dichlorination tranformation is expected to have broad scientific impact, across both academic and industrial settings. Given the diverse array of organic, inorganic and organometallic chemistries to be explored, students are expected to benefit from this broad synthetic training. The PI plans to work to include women and chemists from traditionally underrepresented groups in this research team undertaking.
有了这个EAGER奖,化学合成计划资助教授K.C. Nicolaou试图开发第一个可行的催化,不对称烯烃二氯化。 虽然明显具有高风险,但在本研究中研究的任何烯烃类中的成功将代表高回报,可能对天然产物,药物,工艺和组合化学工作产生影响。 Nicolaou小组将探索互补的有机催化和有机金属途径,以实现标题转化,金鸡纳生物碱的手性支架预计将赋予不对称性,并与相对非极化烯烃和极化烯烃的α,β-不饱和羰基品种进行探索。如果成功,催化不对称二氯化转化预计将产生广泛的科学影响,在学术界和工业界都是如此。 鉴于需要探索的有机、无机和有机金属化学的多样化,预计学生将从这种广泛的合成培训中受益。 PI计划努力将传统上代表性不足的群体中的妇女和化学家纳入这一研究团队。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Kyriacos C. Nicolaou其他文献
Kyriacos C. Nicolaou的其他文献
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{{ truncateString('Kyriacos C. Nicolaou', 18)}}的其他基金
New Synthetic Strategies and Technologies
新的合成策略和技术
- 批准号:
0603217 - 财政年份:2006
- 资助金额:
$ 14.99万 - 项目类别:
Continuing Grant
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