COLLABORATIVE PROJECT: Molecular Studies Of Juvenile Hormone Action

这项由移动通信部门联合支持的拟议研究 生物科学和化学部，是一个 了解保幼激素作用的跨学科项目 在分子水平上结合化学学科， 分子生物学和生理学。 主要关键包括理解 基因表达的激素调节的分子基础 昆虫（L.M. Riddiford），JH的生化和分子研究 代谢与合成（B.D.吊床），并使用高特异性 活性标记的JH和JH（G.D. Prestwich）。 三个有利于 这个项目的结果。 一是科学工作导向 基因表达调控中的一个基本问题， 昆虫的变态在和容易获得和迷人的 本研究的模型系统。 第二，实际影响 这项工作可能会导致新的生物学的发展， 具体和环境上更安全的昆虫控制策略， 农作物害虫 第三，需要进行学科间培训， 参与的学生、博士后研究员和教职研究人员 提高科学探究的质量和广度， 实验室

The proposed research, jointly supported by the Division of Cellular Biosciences and the Division of Chemistry, is the continuation of an interdisciplinary project to understand the action of juvenile hormone at the molecular level combining the disciplines of chemistry, molecular biology, and physiology. Major keys include understanding the molecular basis for hormonal regulation of gene expression in insects (L.M. Riddiford), biochemical and molecular studies of JH metabolism and synthesis (B.D. Hammock), and use of high specific activity labeled JHs and JHs (G.D. Prestwich). Three benefits result from this project. First, the scientific work is directed at a fundamental problem in regulation of gene expression, and the metamorphosis of insects in and easily accessible and fascinating model system for this study. Second, the practical implications of this work may lead to the development of new biologically specific and environmentally safer insect control starategies for crop pest. Third, the interdiscriplinary training required for the students postdoctoral fellow and faculty researchers involved enhances the quality and breadth of scientific inquiry in each laboratory.