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A novel therapeutic approach to pulmonary arterial hypertension - targeting natural killer cells through the interleukin-15 and transforming growth factor-beta pathways.

A novel therapeutic approach to pulmonary arterial hypertension - targeting natural killer cells through the interleukin-15 and transforming growth factor-beta pathways.
一种治疗肺动脉高压的新方法 - 通过白细胞介素 15 和转化生长因子 β 途径靶向自然杀伤细胞。
批准号：
412482
负责人：
Ratsep Matthew T
金额：
$9.83万
依托单位：
Queen's University (Kingston, Ontario)
依托单位国家：
加拿大
项目类别：
Fellowship Programs
财政年份：
2019
资助国家：
加拿大
项目状态：
已结题
起止时间：
2019-10-01 至 2022-10-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=412482&lang=en
关键词：
Blood Pressure Cardiac Catheterization Cardiovascular Cell Biology Cell Therapy Endothelium Genetics Mouse Models Natural Killer Cells Pulmonary Hypertension

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英文摘要
Pulmonary arterial hypertension (PAH) causes narrowing and loss of blood vessels in the lungs, leading to increased stress on the heart and death by heart failure. Treatments for PAH are expensive and provide little benefit to the patient in terms of symp
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Manipulating IL-15 and TGFb signaling augments Natural Killer cell homeostasis and protects from experimental pulmonary arterial hypertension
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