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Manipulating IL-15 and TGFb signaling augments Natural Killer cell homeostasis and protects from experimental pulmonary arterial hypertension

Manipulating IL-15 and TGFb signaling augments Natural Killer cell homeostasis and protects from experimental pulmonary arterial hypertension
操纵 IL-15 和 TGFb 信号传导增强自然杀伤细胞稳态并预防实验性肺动脉高压
批准号：
411933
负责人：
Ratsep Matthew T
金额：
$0.07万
依托单位：
Queen's University (Kingston, Ontario)
依托单位国家：
加拿大
项目类别：
财政年份：
2019
资助国家：
加拿大
项目状态：
已结题
起止时间：
2019-09-01 至 2020-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=411933&lang=en
关键词：
Blood Pressure Cardiac Catheterization Cardiovascular Cell Therapy Echocardiography Endothelium Flow Cytometry Natural Killer Cells Pulmonary Arterial Hypertension Rodent Models

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Pulmonary arterial hypertension (PAH) causes narrowing and loss of blood vessels in the lungs, leading to increased stress on the heart and death by heart failure. Treatments for PAH are expensive and provide little benefit to the patient in terms of symp
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