Cracking the code of snails to elucidate parasite disease transmission

破解蜗牛密码以阐明寄生虫病的传播

• 批准号: DP230100270
• 负责人: A/Prof Neil Young
• 金额: $ 35.32万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP230100270
• 关键词: Cracking; code; snails; elucidate; parasite

In Australia, a disease caused by liver flukes causes major economic losses to livestock production. The role of Australian pond snails as intermediate hosts for this parasite is poorly understood. This project aims to explore the phylogeography, biology and genomics of these snails. It expects to create novel molecular resources for important snail species and verify their roles as key vectors of flatworm parasites. The curation of genomic and transcriptomic data sets, and elucidation of snail–parasite interactions will underpin the development of environmental diagnostic tests and deliver a new generation of intervention strategies to reduce the burden of liver fluke disease through the control of their snail intermediate hosts.

在澳大利亚，一种由肝吸虫引起的疾病给畜牧业生产造成了重大经济损失。澳大利亚池塘蜗牛作为这种寄生虫的中间宿主的作用鲜为人知。该项目旨在探索这些蜗牛的系统地理、生物学和基因组学。它有望为重要的蜗牛物种创造新的分子资源，并验证它们作为扁虫寄生虫关键载体的作用。基因组和转录组数据集的整理，以及蜗牛与寄生虫相互作用的阐明，将为环境诊断测试的开发奠定基础，并提供新一代干预战略，通过控制蜗牛中间宿主来减轻肝吸虫病的负担。