Chemical Factors in the Brain Involved in Ingestive Behavior

大脑中与摄入行为有关的化学因素

• 批准号: 9121656
• 负责人: Robert Myers
• 金额: $ 9万
• 依托单位: East Carolina University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-06-15 至 1996-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9121656&HistoricalAwards=false
• 关键词: Chemical; Factors; Brain; Involved; Ingestive

Vital functions of the body are controlled by complex mechanisms of the brainstem, which involve both hormones and neurotransmitter substances. The research to be performed by Dr. Myers as a result of this award will deal with processes responsible for hunger, the act of feeding, the condition of satiety, experimental anorexia, the regulation of body temperature, hyperthermia and hypothermia. Special emphasis will be placed on the interaction between mechanisms of hunger and of temperature regulation. In specific experiments, the function of a newly discovered protein factor called macrophage inflammatory protein 1 (MIP-1 ) will be studied. This substance is a potent endogenous factor which has been directly implicated in the regulation of hunger and temperature at the level of hypothalamus. The studies will focus on brain sensitivity to MIP- 1 in terms of changes in temperature anf feeding, and the interaction of MIP-1 with other neurotransmitters that are known to be involved in physiological regulation of these functions.This research will contribute fundamental scientific information about how hormones and transmitters in the brain can modulate life-sustaining regulatory functions.

身体的重要功能由脑干的复杂机制控制，其中涉及激素和神经递质物质。迈尔斯博士因获得该奖项而进行的研究将涉及饥饿、进食行为、饱腹感、实验性厌食症、体温调节、体温过高和体温过低的过程。将特别强调饥饿机制和温度调节机制之间的相互作用。在具体实验中，将研究一种新发现的称为巨噬细胞炎症蛋白1（MIP-1）的蛋白质因子的功能。这种物质是一种有效的内源性因子，直接参与下丘脑水平的饥饿和温度调节。这些研究将重点关注大脑对 MIP-1 在温度和进食变化方面的敏感性，以及 MIP-1 与已知参与这些功能的生理调节的其他神经递质的相互作用。这项研究将提供有关大脑中的激素和递质如何调节维持生命的调节功能的基本科学信息。