Ionic Organic Reactions and Their Intermediates

研究将继续对离子有机反应及其 中间体，强调亲电的作用 活化鎓离子、羧鎓离子的（原）溶剂化 和某些碳阳离子系统通过与 杂原子的可用非键合电子对。 一些 将研究潜在的氧鎓和羧鎓双价离子 例如二质子化醇、二质子化CO、二质子化 HCN和双质子化CO2以及双质子化酯。 包括将是实验性的超强酸调查的基础上 同位素交换研究，以及低温 光谱研究和理论研究。 的 还将研究质子化（烷基化）化学。 的 Friedel-Crafts的质子分解（协调）活化 反应将探讨在烷烃的反应，以及 高度失活的芳烃。 卤氧鎓离子和混合 卤代烷基衍生物也将在 氯化反应 Polyhalonium指示将是 硼阳离子也会被探索 寻找持久 硅离子将继续，包括固态29 Si NMR研究。 最近发现的C60衍生化和 C70富勒烯的后续工作包括卤化， 烷基化、去环化等反应。 %%% 有了这个奖项，有机合成计划将支持 乔治博士的研究Olah at the University of Southern 加州。 这项研究将探讨 通过质子与以下物质相互作用形成的双质子化物质： 氧和氮原子上的未共享电子对， 稳定的分子种类。 这些活性物质的化学性质 物种将被研究。 这将导致发展 一些新的独特的合成方法， 生物化学和医学研究以及 化工专业化

Research will continue on ionic organic reactions and their intermediates with emphasis on the role of electrophilic (proto) solvation in activating onium ions, carboxonium ions and certain carbocationic systems by interaction with the available non-bonded electron pairs of the heteroatoms. Some potential oxonium and carboxonium dications will be studied such as diprotonated alcohols, diprotonated CO, diprotonated HCN and diprotonated CO2 as well as diprotonated esters. Included will be experimental superacidic investigations based on isotopic exchange studies, as well as low temperature spectroscopic investigations and theoretical studies. The protolytic (alkylative) chemistry will also be studied. The protolytic (coordinative) activation of the Friedel-Crafts reaction will be explored in reactions of alkanes, as well as highly deactivated aromatics. Halooxonium ions and mixed halo-alkyl derivatives will be also prepared and studied in chlorination reactions. Polyhalonium dications will be explored, as will be bora-cations. The search for persistent silicenium ions will be continued, including solid state 29Si NMR studies. The recently discovered derivatization of C60 and C70 fullerenes will be followed up including halogenation, alkylation, acyclation and other reactions. %%% With this award, the Organic Synthesis Program will support the research of Dr. George A. Olah at the Univeristy of Southern California. The research will explore the generation of diprotonated species formed by the interaction of a proton with the unshared electron pairs on oxygen and nitrogen atoms in stable molecular species. The chemistry of these reactive species will be studied. This will result in the development of some new unique synthetic methodology that should benefit research in biochemistry and medicine as well as in the chemical industry.