New Polyamides with a Protein-Like Structure

具有类蛋白质结构的新型聚酰胺

• 批准号: 9201133
• 负责人: Murray Goodman
• 金额: $ 46.55万
• 依托单位: University of California-San Diego
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-04-01 至 1997-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9201133&HistoricalAwards=false
• 关键词: New; Polyamides; Protein; Like; Structure

This work is directed toward the design of novel polyamides based on the incorporation of sequential and mimetic residues, similar to those found in proteins. The research expects to find new structures which can form biomaterials. The polymers are mimetic structures related to or different from those present in standard nylons and proteins. For the characterization of these polymers, Fourier transform infrared spectroscopy, circular dichroism (where applicable), solution and solid-state nuclear magnetic resonance, electron microscopy and fiber diffraction techniques will be employed. The researchers will also utilize computer simulations to determine the preferred conformations for the polymers and model compounds. The goal is also to design and synthesize a series of optically active polyoxazolines. These polymers represent a broad class of novel peptidomimetic structures. The conformations of these macromolecules and their model compounds will be examined. Both sequence copolymers and the polyoxazolines should have potential uses as sutures, biomedical devices, and drug-delivery matrices. Through a study of structure, conformation and properties, the researchers hope to develop new classes of peptidomimetic polyamides. This program has as its objective the preparation and characterization of complex molecular structures that mimic naturally occurring biopolymers.

这项工作是针对设计的新型聚酰胺基 对序列和模拟残基的掺入，类似于 蛋白质中发现的。 该研究预计将发现新的 可以形成生物材料的结构。 聚合物是模拟的 与标准中存在的结构相关或不同的结构 尼龙和蛋白质。 为了表征这些聚合物， 傅里叶变换红外光谱，圆二色性（其中 适用），溶液和固态核磁共振， 电子显微镜和纤维衍射技术将是 就业。 研究人员还将利用计算机模拟 以确定聚合物和模型的优选构象 化合物. 目标也是设计和合成一系列 光学活性聚恶唑啉。 这些聚合物代表了广泛的 一类新颖的拟肽结构。 的构象 将对这些大分子及其模型化合物进行研究。 序列共聚物和聚恶唑啉均应具有 作为缝合线、生物医学器械和药物输送的潜在用途 矩阵 通过对结构、构象和 研究人员希望开发新的类别， 拟肽聚酰胺。 该方案的目标是 复杂分子结构的制备和表征 模仿天然生物聚合物。