Collagen Mimetic Structures for Novel Biomaterials

9802329古德曼胶原蛋白是脊椎动物中含量最丰富的胞外蛋白，具有独特的三螺旋结构。胶原蛋白具有高强度、低抗原性、低炎性和细胞毒性、促进细胞生长和细胞附着等特点，是开发生物材料的理想材料。PI将设计一类新的胶原蛋白生物材料，结合树枝状结构，从而为胶原蛋白模拟物创建定义的大分子结构域。已经选择了几个核心结构来开发不同的胶原基树枝状大分子家族，这些树枝状大分子可以根据特定的应用进行进一步的操纵。%这个项目由材料研究和分子与细胞生物科学司以及数学与物理科学局多学科活动办公室支持，涉及生物材料领域。胶原基生物材料具有广泛的潜在生物医学应用，包括眼科设备、涂层和粘合剂、生物传感器、植入材料和药物释放系统。树枝状大分子和胶原蛋白的结合是创造新型生物材料的一个令人兴奋的挑战。***

9802329 Goodman Collagen, which forms a unique triple helical structure, is the most abundant extracellular protein in vertebrates. Collagen possesses many favorable characteristics for biomaterials development, including high tensile strength, low antigenicity, low inflammatory and cytotoxic properties, and the ability to promote cellular growth and cellular attachment. The PI will design a new class of collagen biomaterials, incorporating dendrimeric structure, thereby creating defined macromolecular domains for the collagen mimetics. Several core structures have been chosen to develop a diverse family of collagen-based dendrimers, which can be further manipulated for specific applications. %%% This project, supported by the Divisions of Materials Research and Molecular & Cellular Biosciences and by the Office of Multidisciplinary Activities in the Directorate for Mathematical & Physical Sciences is in the area of biomaterials. Collagen- based biomaterials have broad potential biomedical applications, including ocular devices, coatings and adhesives, biosensors, implant materials and drug delivery systems. The combination of dendrimer and collagen properties represents an exciting challenge to create novel biomaterials. ***