Collagen Mimetic Structures for Novel Biomaterials

新型生物材料的胶原模拟结构

• 批准号: 9802329
• 负责人: Murray Goodman
• 金额: $ 11.5万
• 依托单位: University of California-San Diego
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-07-01 至 2001-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9802329&HistoricalAwards=false
• 关键词: Collagen; Mimetic; Structures; Novel; Biomaterials

9802329 Goodman Collagen, which forms a unique triple helical structure, is the most abundant extracellular protein in vertebrates. Collagen possesses many favorable characteristics for biomaterials development, including high tensile strength, low antigenicity, low inflammatory and cytotoxic properties, and the ability to promote cellular growth and cellular attachment. The PI will design a new class of collagen biomaterials, incorporating dendrimeric structure, thereby creating defined macromolecular domains for the collagen mimetics. Several core structures have been chosen to develop a diverse family of collagen-based dendrimers, which can be further manipulated for specific applications. %%% This project, supported by the Divisions of Materials Research and Molecular & Cellular Biosciences and by the Office of Multidisciplinary Activities in the Directorate for Mathematical & Physical Sciences is in the area of biomaterials. Collagen- based biomaterials have broad potential biomedical applications, including ocular devices, coatings and adhesives, biosensors, implant materials and drug delivery systems. The combination of dendrimer and collagen properties represents an exciting challenge to create novel biomaterials. ***

Goodman胶原蛋白是脊椎动物中最丰富的细胞外蛋白，具有独特的三螺旋结构。胶原蛋白具有许多生物材料开发的有利特性，包括高抗张强度，低抗原性，低炎症和细胞毒性，以及促进细胞生长和细胞附着的能力。PI将设计一类新的胶原生物材料，结合树突结构，从而为胶原模拟物创造明确的大分子结构域。已经选择了几个核心结构来开发基于胶原蛋白的树状大分子的不同家族，这些树状大分子可以进一步用于特定应用。该项目由材料研究和分子细胞生物科学部以及数学和物理科学理事会多学科活动办公室支持，属于生物材料领域。胶原蛋白基生物材料具有广泛的生物医学应用潜力，包括眼器械、涂层和粘合剂、生物传感器、植入材料和药物输送系统。树突分子和胶原蛋白特性的结合代表了创造新型生物材料的一个令人兴奋的挑战。* * *