Investigating the Adamts19-dependent mechanisms that regulate valve maturation

研究调节瓣膜成熟的 Adamts19 依赖性机制

• 批准号: 435865
• 负责人: Andelfinger Gregor U
• 金额: $ 79.14万
• 依托单位: Centre hospitalier universitaire Sainte-Justine (Montral, Qubec)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-10-01 至 2025-10-01
• 项目状态: 未结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=435865&lang=en
• 关键词: Adamts19; Animal Models Of Valve Disease; Heart Maturation; Human Cell Atlas; Matrix Metalloproteinases; Single Cell Rna Sequencing; Valve Development; Valvular Interstitial Cells

Heart valves allow blood to flow in only one direction through the heart. They consist of small leaflets, which are pushed open to allow unidirectional blood flow and then close together to seal and prevent backflow. The valves form during early developme

心脏瓣膜只允许血液在心脏中单向流动。它们由小叶组成，小叶被推开以允许单向血液流动，然后关闭在一起以密封和防止回流。瓣膜是在发育早期形成的