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Discovery of OcaB as novel gene modulating longevity in nematodes

Discovery of OcaB as novel gene modulating longevity in nematodes
发现 OcaB 作为调节线虫寿命的新基因
批准号：
191683
负责人：
Picard Frdric
金额：
$3.49万
依托单位：
Institut universitaire de cardiologie et de pneumologie de Qubec - U Laval
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2009
资助国家：
加拿大
项目状态：
已结题
起止时间：
2009-09-01 至 2010-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=191683&lang=en
关键词：
Calorie Restriction Gene Expression Insulin Signaling Lifespan Nematodes Ocab

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英文摘要
We have discovered that OcaB, a gene that controls B cell metabolism and development, is robustly modulated upon aging in adipose tissue, an organ that has been associated with the regulation of lifespan.We discovered that in worms, a reduction in OcaB le
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Control of metabolic inflammaging by traffic of B lymphocytes in adipose tissues
Modulation and effects of IGFBP-2 on brown adipose tissue thermogenesis
Transcriptional control of adipose tissue by OcaB upon aging
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