A Colloquium on Compatible Solutes and Macromolecular Stability

五年前，加州大学博德加海洋实验室举办了一系列座谈会，在座谈会期间，及时召集领域的专家就当前的研究交换意见，并就座谈会的主题进行广泛的公开讨论。这次讨论会得到了广泛的宣传，并吸引了来自世界各地的与会者。本提案是为本系列第五次研讨会提供部分支持。以前的讨论会已经出版，这次讨论会的组织者打算继续这种做法。我们将召集许多研究大分子在各种条件下稳定的世界领导人。会议的重点是“相容溶质”及其在稳定中的作用。演讲者来自广泛的领域，包括食品科学、生物化学、生物物理学、动植物生理学、物理学和化学。由于这一主题在“现实世界”中有明确的应用，因此来自工业界和联邦政府的参与者都被纳入该计划。作为一个跨学科的会议，许多参与者从未见过面，甚至可能不知道彼此的工作。被选中参加这次讨论会的科学家不太可能聚集在一个定期的科学会议上。因此，一个主要的目标是在一个具有基本和应用重要性的主题上产生不可能发生的讨论和互动。

Five years ago the University of California's Bodega Marine Laboratory instituted a series of colloquia, during which experts in timely fields were assembled for an exchange of ideas on current research and to participate in extensive public discussions on the topic of the colloquium. The colloquia are widely advertised and have been well attended by participants from all over the world. This proposal is for partial support for the fifth colloquium in this series. Previous colloquia have been published, a practice which the organizers of the proposed one intend to continue. We will assemble many of the world leaders whose research focuses on the stabilization of macromolecules under a variety of conditions. The focus of the meeting is specifically on "compatible solutes" and their roles in stabilization. The speakers are chosen from far-flung fields, including food science, biochemistry, biophysics, animal and plant physiology, physics and chemistry. Because this subject has clear applications in "the real world", participants from industry and Federal government are included in the program. Being an interdisciplinary meeting, many of the participants have never met and may not even be aware of each other's work. It is unlikely that the scientists chosen to participate in this colloquium would be assembled at a regular scientific meeting. Thus, a major aim is to generate discussion and interaction that would not likely otherwise occur, on a topic of basic and applied importance.