A multifaceted technology platform to enhance single cell genomics

增强单细胞基因组学的多方面技术平台

• 批准号: LE230100090
• 负责人: Prof Ian Paulsen
• 金额: $ 45.53万
• 依托单位: Macquarie University
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Infrastructure, Equipment and Facilities
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LE230100090
• 关键词: multifaceted; technology; platform; enhance; single

A major limitation of traditional cellular studies is that they scrutinise DNA or RNA extracted from thousands of cells, resulting in a population average of what is there. This blunt approach misses key differences and interactions between cells in populations. This project aims to build capacity within the Ramaciotti Centre Consortium for single cell genomics by acquiring equipment for enhanced sorting or spatial mapping of single cells. This will enable innovative science across diverse fields including industrial biotechnology, environmental microbiology, neurobiology, and biosecurity and ensure that Australian researchers remain at the forefront of single cell genomics in organisms ranging from bacteria to animals to humans.

传统细胞研究的一个主要局限性是，他们仔细检查从数千个细胞中提取的DNA或RNA，结果是那里的总体平均水平。这种直截了当的方法忽略了种群中细胞之间的关键差异和相互作用。该项目旨在通过购置设备加强单细胞分类或绘制单细胞空间图，在拉马西奥蒂中心联合体内建立单细胞基因组学能力。这将使包括工业生物技术、环境微生物学、神经生物学和生物安全在内的不同领域的创新科学成为可能，并确保澳大利亚研究人员在从细菌到动物再到人类的各种生物中保持在单细胞基因组学的前沿。