A multifaceted technology platform to enhance single cell genomics

传统细胞研究的一个主要限制是，它们要仔细检查从数千个细胞中提取的DNA或RNA，从而得出一个平均数量。这种生硬的方法忽略了种群中细胞之间的关键差异和相互作用。该项目旨在通过获得单细胞增强分选或空间制图的设备，在Ramaciotti中心联盟内部建立单细胞基因组学能力。这将使包括工业生物技术、环境微生物学、神经生物学和生物安全在内的不同领域的创新科学成为可能，并确保澳大利亚的研究人员在从细菌到动物再到人类的有机体的单细胞基因组学方面保持领先地位。

A major limitation of traditional cellular studies is that they scrutinise DNA or RNA extracted from thousands of cells, resulting in a population average of what is there. This blunt approach misses key differences and interactions between cells in populations. This project aims to build capacity within the Ramaciotti Centre Consortium for single cell genomics by acquiring equipment for enhanced sorting or spatial mapping of single cells. This will enable innovative science across diverse fields including industrial biotechnology, environmental microbiology, neurobiology, and biosecurity and ensure that Australian researchers remain at the forefront of single cell genomics in organisms ranging from bacteria to animals to humans.