Anthropology Histories of Selected New World Populations Based on Nuclear DNA Polymorphisms

本研究的主要目标是进行试点 Alu序列插入多态性的研究 新世界的人口。 以前的研究在 研究人员的实验室表明，大多数核RFLPs是 在许多人群中是多态的。 在这里，调查人员 我将分析第二种多态性作为工具的效用 来重建人类的历史。 因为 关于土著人之间关系的丰富知识 美国人口和样本的可用性，该系统 将在这个群体中进行测试。 Alu序列构成了一个散布在 在细胞核基因组中， 基因组 因为序列基本上不可能 通过独立突变插入到完全相同的位置， 发现相同的Alu序列插入是假定的证据 共同的血统。研究人员将测试这些工具的效用。 多态性作为遗传标记。 此外，研究人员 将调查特定Alu多态性的古老性， 与其他人群的样本进行比较。

The primary objective of this research is to conduct a pilot investigation of the insertional polymorphism of Alu sequences in New World human populations. Previous research in the investigators' laboratory has shown that most nuclear RFLPs are polymorphic in many human populations. Here, the investigators will analyze the utility of a second type of polymorphism as a tool for reconstructing the history of human populations. Because of the wealth of knowledge regarding relationships between Native American populations and the availability of samples, the system will be tested on this group. Alu sequences constitute a family of related sequences scattered throughout the nuclear genome which are capable of moving within the genome. As it is essentially impossible for a sequence to insert in exactly the same position through independent mutations, finding identical Alu sequences insertions is presumptive evidence of common descent. The investigators will test the utility of these polymorphisms as genetic markers. Additionally, the researchers will investigate the antiquity of specific Alu polymorphisms by comparison with samples from other human populations.