Dissertation Research: Evoultionary Genetics of Gorillas (Gorilla gorilla) Using Nuclear Autosomal Haplotypes

论文研究：利用核常染色体单倍型进行大猩猩（Gorilla gorilla）的进化遗传学

• 批准号: 9900100
• 负责人: Kenneth Kidd
• 金额: $ 1.2万
• 依托单位: Yale University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-04-01 至 2001-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9900100&HistoricalAwards=false
• 关键词: Dissertation; Research; Evoultionary; Genetics; Gorillas

The objective of this project is to determine the amount and pattern of genetic diversity in the gorilla (Gorilla gorilla), by determining the DNA sequence variation at three independent nuclear loci in representatives from all three gorilla subspecies, as well as from comparable samples of chimpanzees, humans, and orangutans. These data will placed in a biogeographical perspective to be used to determine aspects of the evolutionary history of the gorilla, including the phylogenetic relationships between subspecies, the timing of the splits between subspecies, and past demographic events such as severe population bottlenecks. Special emphasis will be placed on the taxonomy of gorillas, particularly on the use of genetic data to help determine the number of living gorilla species. By comparing the pattern of genetic diversity observed in gorillas to that of chimps and humans, this project will also help in understanding the evolution of our own species, by providing a comparative framework in which to place the large and growing body of data on human genetic evolution. In addition, understanding the genetic substructure of gorillas may help in developing conservation programs for these highly endangered apes.

该项目的目的是确定大猩猩（Gorilla gorilla）的遗传多样性的数量和模式，通过确定所有三个大猩猩亚种代表的三个独立核基因座的DNA序列变异，以及黑猩猩，人类和猩猩的可比样本。 这些数据将被放置在一个地理学的角度来确定大猩猩的进化历史的各个方面，包括亚种之间的系统发育关系，亚种之间的分裂的时间，以及过去的人口统计事件，如严重的人口瓶颈。 将特别强调大猩猩的分类学，特别是利用遗传数据帮助确定大猩猩物种的数量。 通过比较在大猩猩与黑猩猩和人类中观察到的遗传多样性模式，该项目还将通过提供一个比较框架来放置关于人类遗传进化的大量和不断增长的数据来帮助理解我们自己物种的进化。 此外，了解大猩猩的遗传结构可能有助于为这些高度濒危的猿类制定保护计划。