SGER: Calcium and Excitation of Isolated Drosophila Photoreceptors

SGER：离体果蝇光感受器的钙和激发

• 批准号: 9210096
• 负责人: Peter O'Day
• 金额: $ 4.8万
• 依托单位: University of Oregon Eugene
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-06-15 至 1994-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9210096&HistoricalAwards=false
• 关键词: SGER; Calcium; Excitation; Isolated; Drosophila

A central unresolved question in visual physiology and biochemistry is: How does light cause the creation of nerve signals in the retina? This process is called "visual transduction." Nerve signals generated during transduction are further processed and encoded by higher-order cells in the retina and ultimately, in the brain. Exciting new developments in genetics, biochemistry, and electrophysiology have made the Drosophila (fruit fly) visual system a new model preparation with which to examine visual transduction. This elegantly simple experimental system promises to yield rapid advances in our understanding of the physiology and biochemistry of biological signalling. In particular, this research will offer a new scientific description of crucial intracellular events in visual transduction, by studying the isolated photoreceptor preparation. Using light- induced introduction of calcium ions into the intracellular space of a single photoreceptor will also enable a variety of significant questions to be answered in this model preparation that will have major significance for understanding the processes of visual transduction that occur, generally, in other species.

视觉生理学和生物化学中一个尚未解决的中心问题 问题是：光是如何在大脑中产生神经信号的？ 视网膜？ 这个过程被称为“视觉传导。“神经 在转导期间产生的信号被进一步处理， 由视网膜中的高级细胞编码， 个脑袋 令人兴奋的新发展，遗传学，生物化学， 电生理学使果蝇具有视觉 一种新的模型制备系统，用于检查视觉 转导 这个优雅简单的实验系统保证了 使我们对生理学的理解迅速发展， 生物信号的生物化学。 特别是，这项研究将提供一个新的科学 描述视觉传导中的关键细胞内事件， 通过研究离体光感受器制备。 利用光- 诱导钙离子进入细胞内空间 单个感光体的光吸收也将使各种重要的 在此模型准备中需要回答的问题， 对理解视觉过程的重要意义 一般来说，在其他物种中发生的转导。