U.S.-Chile Cooperative Research: Role of IP3-Receptor in Visual Transduction

美国-智利合作研究：IP3 受体在视觉传导中的作用

• 批准号: 9604977
• 负责人: Peter O'Day
• 金额: $ 2.96万
• 依托单位: University of Oregon Eugene
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-06-15 至 2000-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9604977&HistoricalAwards=false
• 关键词: U.S.; Chile; Cooperative; Research; Role

9604977 O'Day This Americas Program award will fund a 3-year cooperative research project between Dr. Peter O'Day, University of Oregon, and Dr. Juan Bacigalupo, University of Chile, on a study of the role of IP3-Receptor in visual transduction, the orchestration of retinal biochemistry that generates visual excitation. The investigators will focus on the question of how two specific biochemical signaling pathways interact in visual transduction in retinal cells from Drosophila. Whether direct interaction between the two pathways is fundamental to transduction is an important question whose examination may provide models for other transducing systems. The researchers intend to use biophysical and biochemical approaches with mutational analysis to examine the connection. The proposed work is important, not only for understanding the biochemical orchestration of invertebrate visual transduction, but also for bringing out some fundamental issues of signal transduction The collaboration will facilitate the exchange of scientific information, technologies, and strategies, thereby enhancing and broadening the experimental approaches available for the long term programs of both groups. ***

小行星9604977 该美洲计划奖将资助俄勒冈州大学的Peter O'Day博士和智利大学的Juan Bacigalupo博士之间的一项为期3年的合作研究项目，研究IP3受体在视觉转导中的作用，即产生视觉兴奋的视网膜生物化学的协调。研究人员将集中研究两种特定的生化信号通路如何在果蝇视网膜细胞的视觉转导中相互作用。 这两条通路之间的直接相互作用是否是转导的基础是一个重要的问题，其研究可能为其他转导系统提供模型。研究人员打算使用生物物理和生物化学方法与突变分析来检查这种联系。 这项工作不仅对理解无脊椎动物视觉信号转导的生化协调机制很重要，而且对揭示信号转导的一些基本问题也很重要。这项合作将促进科学信息、技术和战略的交流，从而加强和扩大两个小组长期计划的实验方法。 ***