U.S.-Chile Cooperative Research: Light-Activated Ion Channels in Visual Receptors

小行星9301719 这个美国-智利奖将支持尤金的俄勒冈州大学的Peter O 'Day博士与智利大学的Juan Bacigalupo博士进行研究合作。 研究人员将研究果蝇光感受器中光激活通道的门控，并测试转导中涉及不止一种生化途径的概念。 光被转换成电信号的机制还不清楚。 该研究的总体目标是提高我们对果蝇光感受器中视觉信号转导以及信号转导通路的激活和调节的理解。 由于它与其他生物系统的相似性，并且由于它可以被遗传操纵以及电生理学研究，因此使用果蝇作为模型系统将为一般细胞信号传导中的类似问题提供重要线索。 ***

9301719 O'Day This U.S.-Chile award will support Dr. Peter O'Day, of the University of Oregon, Eugene, in a research collaboration with Dr. Juan Bacigalupo, of the University of Chile. The researchers will investigate the gating of light-activated channels in Drosophila photoreceptors and test the concept that there is more than one biochemical pathway involved in transduction. The mechanism by which light is transduced to an electrical signal is still unclear. The overall goal of the research is to enhance our understanding of visual transduction in Drosophila photoreceptors and the activation and modulation of transduction pathways. Because of its similarities to other biological systems, and because it can be genetically manipulated as well as electro- physiologically studied, the use of Drosophila as a model system will provide important clues to similar issues in cellular signalling in general. ***