Workshop on: "Molecular Biology of Mitochondrial Transport System; Ostuni, Italy, September 30 - October 3, 1992.

研讨会：“线粒体运输系统的分子生物学；意大利奥斯图尼，1992 年 9 月 30 日至 10 月 3 日。

• 批准号: 9211759
• 负责人: Michael Forte
• 金额: $ 0.72万
• 依托单位: Oregon Health & Science University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-07-01 至 1993-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9211759&HistoricalAwards=false
• 关键词: Workshop; Molecular; Biology; Mitochondrial; Transport

The vast majority of eukaryotic cells contain many mitochondria. In this organelle, the oxidation of small molecules generates cellular ATP, thus providing most of the available energy for the cell. A unique feature of mitochondria and related intracellular organelles is that they are composed of two independent yet interacting membrane systems. Embedded in both of these membranes are a variety of channel and carrier molecules that are responsible for the monumental biochemical tasks necessitated by this structure; the transport of highly charged molecules into and out of the mitochondria. Many of the molecules responsible for these transport processes have been identified and characterized in recent months. Many of the recent advances in the field have been made by investigators applying disparate technologies and methodologies. This workshop on "Molecular Biology of Mitochondrial Transport System" will bring together scientists examining these systems by different approaches to begin to identify structural similarities and functionally important interactions. Although many of the individual players are known, the nature of potential functional interactions and conserved structural motifs have yet to be thoroughly explored. It is both important and timely to bring together a multidisciplinary group of investigators examining mitochondrial transport systems by different approaches but with the same overall goal.

绝大多数真核细胞含有许多线粒体。在这个细胞器中，小分子的氧化产生细胞三磷酸腺苷，从而为细胞提供大部分可用能量。线粒体和相关的细胞内细胞器的一个独特特征是它们由两个独立但相互作用的膜系统组成。嵌入在这两种膜中的是各种通道和载体分子，它们负责这种结构所必需的巨大的生化任务；高电荷分子进出线粒体的运输。近几个月来，许多负责这些运输过程的分子已经被确定和表征。该领域最近的许多进展都是由调查人员应用不同的技术和方法取得的。这次关于“线粒体运输系统的分子生物学”的研讨会将使科学家们聚集在一起，通过不同的方法研究这些系统，以开始确定结构上的相似性和重要的功能相互作用。虽然许多单独的参与者是已知的，但潜在的功能相互作用和保守的结构基序的性质尚未得到彻底的探索。召集一个多学科的研究小组，通过不同的方法但具有相同的总体目标来检查线粒体运输系统，这既重要又及时。