Workshop on the Molecular and Cellular Biology of Plasminogen Activation

纤溶酶原激活的分子和细胞生物学研讨会

• 批准号: 8528219
• 负责人: Victoria Ploplis
• 金额: $ 0.5万
• 依托单位: UNIVERSITY OF NOTRE DAME
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-03-01 至 2014-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8528219
• 关键词: Alteplase; Area; Biochemistry; Biology; Biotechnology; Clinical Medicine; Collaborations; Complex; Country; Denmark; Development; Educational workshop; Enzyme Precursors; Fostering; Functional disorder; Future; Genes; Hemostatic function; Infection; Inflammation; International; Italy; Knock-out; Laboratories; Minority; Molecular and Cellular Biology; Neuropathy; Oral; Pathology; Pathway interactions; Peptide Hydrolases; Physiological; Physiology; Plasma; Plasmin; Plasminogen; Plasminogen Activator Inhibitor 1; Postdoctoral Fellow; Process; Proteolysis; Proteolytic Processing; Regulation of Proteolysis; Research; Research Personnel; Scientist; Serine Protease; Serpins; Stroke; Students; System; Technology; Time; United States; Urokinase; Woman; Work; abstracting; angiogenesis; extracellular; graduate student; in vivo Model; inhibitor/antagonist; meetings; new technology; next generation; posters; programs; public health relevance; symposium; therapeutic development; tumor progression

DESCRIPTION (provided by applicant): Activation of the fibrinolytic system ultimately results in the proteolytic conversion of the plasma zymogen, plasminogen (Pg), to the serine protease plasmin (Pm) (1). The major inhibitor of Pg activation, Plasminogen Activator Inhibitor-1 (PAI-1), regulates this process at the level of the primary physiological activators, urokinase-type plasminogen activator (uPA) and tissue-type plasminogen activator (tPA), resulting in formation of stable serpin/protease complexes. The field of plasminogen activation has changed dramatically over the past few years due to rapid advances in the field. Over the decades, contributions from laboratory discoveries have been uniquely important for the development of new therapies in the field of hemostasis, including recombinant tissue plasminogen activator, thrombolytics, and anti-thrombolytics. Additionally, during this time, plasminogen, plasmin, and its activators and inhibitors, have been shown to be involved in a number of physiologies and pathophysiologies, e.g., hemostasis, inflammation, infection, neuropathies,-many discovered through the development of gene knock-out technologies and in vivo models. The purpose for establishing the Workshop on Molecular and Cellular Biology of Plasminogen Activation, over 27 years ago, was to encourage collaborations between different countries working in the area of plasminogen biochemistry and biology. It is a Workshop that has a tradition of presentations by junior, as well as senior investigators, and of encouraging the attendance and participation of women, minorities, graduate students, and postdoctoral researchers. This workshop is unique in that the program is highly abstract-driven. This allows for the emphasis of the meeting to be on new and unpublished research, which will foster productive interchange of ideas between attendees of the meeting. The Specific Aims of the workshop are: (1) to provide a venue for young and senior investigators to present and discuss, in an informal setting, cutting-edge research results in the biochemistry and physiology of plasminogen activation and extracellular proteolysis. (2) To allow for the dissemination of new technologies related to this field of work. (3) To discuss the latest therapeutic developments for regulating these functions during various pathologies. Continuation of this workshop will help to assure the development of the next generation of scientists who will become the future of this field.

描述（由申请人提供）：纤溶系统的激活最终导致血浆酶原纤溶酶原 (Pg) 蛋白水解转化为丝氨酸蛋白酶纤溶酶 (Pm) (1)。 Pg 激活的主要抑制剂纤溶酶原激活剂抑制剂-1 (PAI-1) 在主要生理激活剂、尿激酶型纤溶酶原激活剂 (uPA) 和组织型纤溶酶原激活剂 (tPA) 水平上调节这一过程，从而形成稳定的丝氨酸蛋白酶抑制剂/蛋白酶复合物。由于纤溶酶原激活领域的快速发展，该领域在过去几年中发生了巨大变化。几十年来，实验室发现的贡献对于止血领域新疗法的开发尤其重要，包括重组组织纤溶酶原激活剂、溶栓剂和抗溶栓剂。此外，在此期间，纤溶酶原、纤溶酶及其激活剂和抑制剂已被证明参与许多生理学和病理生理学，例如止血、炎症、感染、神经病——许多是通过基因敲除技术和体内模型的发展发现的。 27 多年前建立纤溶酶原激活分子和细胞生物学研讨会的目的是鼓励不同国家在纤溶酶原生物化学和生物学领域开展合作。该研讨会有由初级和高级研究人员进行演讲的传统，并鼓励女性、少数族裔、研究生和博士后研究人员出席和参与。本次研讨会的独特之处在于该项目是高度抽象驱动的。这使得会议的重点可以放在新的和未发表的研究上，这将促进与会者之间富有成效的思想交流。研讨会的具体目标是：（1）为年轻和资深研究人员提供一个在非正式场合展示和讨论纤溶酶原激活和细胞外蛋白水解的生物化学和生理学前沿研究成果的场所。 (2) 允许传播与该工作领域相关的新技术。 (3) 讨论在各种病理过程中调节这些功能的最新治疗进展。本次研讨会的继续举办将有助于确保下一代科学家的发展，他们将成为该领域的未来。