U.S.-Hungary Cooperative Research on Mathematical Models of the Cell Division Cycle

美国-匈牙利细胞分裂周期数学模型合作研究

• 批准号: 9212471
• 负责人: John Tyson
• 金额: $ 3.19万
• 依托单位: Virginia Polytechnic Institute and State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-01-15 至 1996-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9212471&HistoricalAwards=false
• 关键词: U.S.; Hungary; Cooperative; Research; Mathematical

This U.S.-Hungary research project on "Mathematical Models of the Cell Division Cycle" is between Dr. John J. Tyson of Virginia Polytechnic Institute & State University, and Dr. Bela Novak of the Technical University, Budapest. Recent molecular studies have revealed four classes of proteins that participate prominently in the division control mechanism. Two proteins (cdc2 and cyclin) combine to form a heterodimer ("mitosis promoting factor," or MPF) that, when activated, triggers all the major events of mitosis and cell division. The activity of MPF is, in turn, controlled by protein kinases and protein phosphatases that determine the phosphorylation state of MPF. The goal of this joint project is to develop mathematical models of the cell division cycle, in order to build secure, reliable connections between molecular details of the control mechanism and classical observations of the behavior of the intact regulatory system. The model will describe the regulation of the MPF activity by phosphorylation, and how the phosphorylation state of MPF is determined by the DNA-to-protein ratio of the cell. The research should yield a mathematical tool to refine assumptions and guide reasoning about the essential events of cell growth and division. This research in cell biology and mathematics fulfills the program objective of advancing science by enabling leading experts in the United States and Hungary to combine complementary talents and pool research resources in areas of strong mutual interest and competence.

这个美国-匈牙利研究项目： 细胞分裂周期”是由弗吉尼亚州的约翰·泰森博士 州立大学理工学院， 技术大学，布达佩斯。 最近的分子研究 揭示了四种蛋白质参与了 在分工控制机制上突出。 两种蛋白质 (cdc2和细胞周期蛋白）联合收割机形成异二聚体（“有丝分裂 促进因子，”或MPF），当激活时，触发所有的 有丝分裂和细胞分裂的主要事件。 强积金的活动 是由蛋白激酶和蛋白质 决定MPF磷酸化状态的磷酸酶。 这个联合项目的目标是开发数学模型 细胞分裂周期，以建立安全，可靠 控制机制的分子细节 和对完整的动物行为的经典观察 监管体系 该模型将描述的监管 MPF的磷酸化活性，以及磷酸化 MPF的状态由MPF的DNA与蛋白质的比率决定。 cell. 这项研究应该会产生一个数学工具来完善 假设和指导推理的基本事件 细胞生长和分裂。 这项细胞生物学和数学的研究实现了 通过使领导能够推动科学发展的计划目标 美国和匈牙利的专家将联合收割机 人才和集中研究资源的领域，强相互 兴趣和能力。