U.S.-Hungary Cooperative Research on Mathematical Models of the Cell Division Cycle

美国-匈牙利细胞分裂周期数学模型合作研究

• 批准号: 9212471
• 负责人: John Tyson
• 金额: $ 3.19万
• 依托单位: Virginia Polytechnic Institute and State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-01-15 至 1996-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9212471&HistoricalAwards=false
• 关键词: U.S.; Hungary; Cooperative; Research; Mathematical

This U.S.-Hungary research project on "Mathematical Models of the Cell Division Cycle" is between Dr. John J. Tyson of Virginia Polytechnic Institute & State University, and Dr. Bela Novak of the Technical University, Budapest. Recent molecular studies have revealed four classes of proteins that participate prominently in the division control mechanism. Two proteins (cdc2 and cyclin) combine to form a heterodimer ("mitosis promoting factor," or MPF) that, when activated, triggers all the major events of mitosis and cell division. The activity of MPF is, in turn, controlled by protein kinases and protein phosphatases that determine the phosphorylation state of MPF. The goal of this joint project is to develop mathematical models of the cell division cycle, in order to build secure, reliable connections between molecular details of the control mechanism and classical observations of the behavior of the intact regulatory system. The model will describe the regulation of the MPF activity by phosphorylation, and how the phosphorylation state of MPF is determined by the DNA-to-protein ratio of the cell. The research should yield a mathematical tool to refine assumptions and guide reasoning about the essential events of cell growth and division. This research in cell biology and mathematics fulfills the program objective of advancing science by enabling leading experts in the United States and Hungary to combine complementary talents and pool research resources in areas of strong mutual interest and competence.

这项关于“细胞分裂周期的数学模型”的美国-匈牙利研究项目由弗吉尼亚理工学院暨州立大学的 John J. Tyson 博士和布达佩斯技术大学的 Bela Novak 博士共同开展。 最近的分子研究揭示了四类蛋白质在分裂控制机制中发挥着重要作用。 两种蛋白质（cdc2 和细胞周期蛋白）结合形成异二聚体（“有丝分裂促进因子”或 MPF），当激活时，会触发有丝分裂和细胞分裂的所有主要事件。 MPF 的活性反过来又受决定 MPF 磷酸化状态的蛋白激酶和蛋白磷酸酶控制。 该联合项目的目标是开发细胞分裂周期的数学模型，以便在控制机制的分子细节与完整调节系统行为的经典观察之间建立安全、可靠的联系。 该模型将描述磷酸化对 MPF 活性的调节，以及细胞的 DNA 与蛋白质比率如何确定 MPF 的磷酸化状态。 这项研究应该产生一种数学工具来完善假设并指导对细胞生长和分裂的基本事件的推理。 这项细胞生物学和数学研究通过使美国和匈牙利的领先专家能够在共同感兴趣和能力强的领域结合互补人才并汇集研究资源，实现了推进科学发展的计划目标。