Mathematical Models of the Cell Division Cycle

细胞分裂周期的数学模型

• 批准号: 9600536
• 负责人: John Tyson
• 金额: $ 5.05万
• 依托单位: Virginia Polytechnic Institute and State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-08-01 至 1998-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9600536&HistoricalAwards=false
• 关键词: Mathematical; Models; Cell; Division; Cycle

Abstract 9600536 Tyson The cell division cycle is the periodic repetition of a sequence of events, including DNA synthesis, mitosis and cytokinesis, that transform a single cell into two daughter cells. Control of the sequence and timing of these events is complex. The major events are triggered by cyclin-dependent kinases, a family of enzymes whose activity depends on binding to the cyclin proteins, phosphorylation and binding to inhibitory proteins. So far characterization of this regulatory system has been reductionistic; breaking the nnetwork into parts and examining how they interact. This project will develop mathematical methods by which the parts can be put back together into a model of an intact, functional regulatory system. By comparing the behavior of the model to experimental observations, the credibility of the model can be judged. The goal is to develop realistic models of cell cycle control in frog embryos, yeast cells and mammalian cells. The experimental tools to dissect this control system are well developed, but the theoretical tools necessary to put the pieces together are still largely untested and underappreciated by cell biologists. This projects aims at developing appropriate mathematical tools, applying them to current data, and communicating the power of modeling the to the experimental community. ***

摘要9600536泰森 细胞分裂周期是一系列事件的周期性重复，包括DNA合成，有丝分裂和胞质分裂，将单个细胞转化为两个子细胞。 控制这些事件的顺序和时间是复杂的。 主要事件由细胞周期蛋白依赖性激酶触发，这是一个酶家族，其活性取决于与细胞周期蛋白的结合、磷酸化和与抑制蛋白的结合。 到目前为止，这种调节系统的特征一直是还原论的;将网络分成几部分，并检查它们如何相互作用。 该项目将开发数学方法，通过这些方法可以将各个部分重新组合成一个完整的功能性监管系统模型。 通过将模型的行为与实验观察进行比较，可以判断模型的可信度。 其目标是在青蛙胚胎、酵母细胞和哺乳动物细胞中建立细胞周期控制的现实模型。 解剖这个控制系统的实验工具已经很发达了，但是把这些碎片放在一起所必需的理论工具在很大程度上还没有经过测试，也没有得到细胞生物学家的重视。 该项目旨在开发适当的数学工具，将其应用于当前数据，并将建模的力量传达给实验社区。 ***