Dissertation Research: Genetic History of Phosphoglucose Isomerase in Colias and the Coliadinae

论文研究：Colias 和 Coliadinae 磷酸葡萄糖异构酶的遗传史

• 批准号: 9212968
• 金额: $ 1.09万
• 依托单位: Stanford University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-12-15 至 1995-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9212968&HistoricalAwards=false
• 关键词: Dissertation; Research; Genetic; History; Phosphoglucose

This research is designed to investigate the dynamics of change at the molecular level. It uses the enzyme phosphoglucose isomerase in the genus Colias (the sulphur butterfly) as an experimental model. The major focus of this research involves a comparison of PGI DNA sequences within and between species of Colias and related genera. Sequence changes will then be interpreted in relation to three dimensional structural information on PGI, the phylogenetic relationships of the butterflies involved, and previous studies on Colias PGI. In addition, this information will be used to address relationships within the Coliadinae, which includes Colias. One of the potential real benefits of the proposed research is that a more accurate picture of selective forces on PGI associated with the structure and function of this protein will be obtained.

本研究旨在调查 在分子水平上发生变化。 它利用磷酸葡萄糖酶 异构酶在属Colias（硫蝴蝶）作为一种 实验模型 这项研究的主要重点涉及一个 PGI DNA序列的物种内和物种之间的比较 大肠杆菌和相关属。 序列变化将被 与三维结构信息相关的解释 在PGI上，涉及的蝴蝶的系统发育关系， 以及之前对PGI大肠杆菌的研究 此外，这些信息 将被用来解决Coliadinae内部的关系， 包括Colias。 一个潜在的真实的好处是 建议的研究是，一个更准确的图片选择性 PGI上与此结构和功能相关的力 将获得蛋白质。