Determining the impact of inosine-producing microbes in promoting the efficacy and modulating toxicity of immune checkpoint blockade therapy in cancer.
确定产生肌苷的微生物对促进癌症免疫检查点阻断疗法的疗效和调节毒性的影响。
基本信息
- 批准号:445416
- 负责人:
- 金额:$ 71.06万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Operating Grants
- 财政年份:2021
- 资助国家:加拿大
- 起止时间:2021-04-01 至 2026-04-01
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
Immune checkpoint blockade therapy (ICBT) is a very promising anti-cancer strategy that harnesses the therapeutic potential of the immune system. ICBT is now successfully used in a wide range of human cancers and has revolutionized the treatment of cancer
免疫检查点阻断疗法(ICBT)是一种非常有前途的抗癌策略,它利用了免疫系统的治疗潜力。ICBT现已成功用于多种人类癌症,并为癌症治疗带来了革命性变化
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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McCoy Kathy其他文献
McCoy Kathy的其他文献
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{{ truncateString('McCoy Kathy', 18)}}的其他基金
Understanding how the maternal microbiota, metabolites and maternal antibodies interact to shape development of the neonatal immune system.
了解母体微生物群、代谢物和母体抗体如何相互作用以塑造新生儿免疫系统的发育。
- 批准号:
402312 - 财政年份:2019
- 资助金额:
$ 71.06万 - 项目类别:
Operating Grants
Integrated Microbiome Platforms for Advancing Causation Testing and Translation (IMPACTT)
用于推进因果关系测试和转化的集成微生物组平台 (IMPACTT)
- 批准号:
382993 - 财政年份:2018
- 资助金额:
$ 71.06万 - 项目类别:
IMPACTT: A Microbiome Research Core based on Integrated Microbiome Platforms for Advancing Causation Testing and Translation
IMPACTT:基于集成微生物组平台的微生物组研究核心,用于推进因果关系测试和翻译
- 批准号:
392480 - 财政年份:2018
- 资助金额:
$ 71.06万 - 项目类别:
相似国自然基金
基于“化痰散结”理论的蚕梅方通过Bifidobacteria菌群激活cGAS-STING通路触发免疫反应防治肠道腺瘤癌变的机制研究
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- 批准年份:2023
- 资助金额:30 万元
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从分子结构了解利他双歧杆菌通过人类聚糖结合的肠道生存策略
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23H00322 - 财政年份:2023
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Elucidation of the gene expression profile of bifidobacteria in the gut microbiota: development of selective recovery method
阐明肠道微生物群中双歧杆菌的基因表达谱:开发选择性恢复方法
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Development of Functional Extracellular Vesicles Based on the Glucose Metabolism Mechanism of Bifidobacteria and Their Application to Cancer Immunotherapy
基于双歧杆菌葡萄糖代谢机制的功能性细胞外囊泡的研制及其在癌症免疫治疗中的应用
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20K20205 - 财政年份:2020
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$ 71.06万 - 项目类别:
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Effects of sulfomucin-binding bifidobacteria on intestinal barrier function and analysis of gut colonization mechanisms
磺粘蛋白结合双歧杆菌对肠道屏障功能的影响及肠道定植机制分析
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19K06374 - 财政年份:2019
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The development of the drug delivery system via recombinant bifidobacteria aiming for an anti-cancer TNF-alpha preparation without adverse side effects.
通过重组双歧杆菌开发药物输送系统,旨在开发无不良副作用的抗癌 TNF-α 制剂。
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19K07172 - 财政年份:2019
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The application of the drug delivery system by recombinant bifidobacteria to overcome the weak point of the low-molecule anticancer STAT3 inhibitors.
应用重组双歧杆菌给药系统克服小分子抗癌STAT3抑制剂的弱点。
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18K06755 - 财政年份:2018
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$ 71.06万 - 项目类别:
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Sugar utilization strategy of bifidobacteria that supports the symbiosis with their hosts
支持与宿主共生的双歧杆菌糖利用策略
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