Cryo correlative Focused Ion Beam, a new frontier in structural biology

冷冻相关聚焦离子束，结构生物学的新前沿

• 批准号: LE230100099
• 负责人: Prof Eric Hanssen
• 金额: $ 45.68万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Infrastructure, Equipment and Facilities
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LE230100099
• 关键词: Cryo; correlative; Focused; Ion; Beam

This project aims to establish the first fully integrated cryogenic correlative focused ion beam instrument in Australia. Focused ion beam microscopes are rapidly evolving instruments that harness the properties of ions to remove unwanted material from specimens. Integration of a fluorescent optical microscope within the same instrument will allow the targeted imaging of bio/material interfaces, cell and protein structure in their native environment. The potential innovations, applications and benefits to society are far reaching, with the facility expected to impact the development of atomic-scale imaging of protein structures for future drug development, biological processes and materials for advanced technology and manufacturing

该项目旨在建立澳大利亚第一台完全集成的低温相关聚焦离子束仪器。聚焦离子束显微镜是一种快速发展的仪器，它利用离子的特性从样品中去除不需要的物质。在同一仪器内集成荧光光学显微镜将允许在其天然环境中对生物/材料界面、细胞和蛋白质结构进行有针对性的成像。潜在的创新，应用和社会效益是深远的，该设施预计将影响未来药物开发，生物工艺和先进技术和制造材料的蛋白质结构原子级成像的发展