Cryo correlative Focused Ion Beam, a new frontier in structural biology

该项目旨在建立澳大利亚第一台全集成低温相关聚焦离子束仪器。聚焦离子束显微镜是一种快速发展的仪器，它利用离子的性质从样品中去除不需要的物质。将荧光光学显微镜集成在同一仪器中，将允许对其自然环境中的生物/材料界面、细胞和蛋白质结构进行定向成像。潜在的创新、应用和对社会的好处是深远的，预计该设施将影响原子级蛋白质结构成像的发展，用于未来的药物开发、生物过程以及先进技术和制造的材料

This project aims to establish the first fully integrated cryogenic correlative focused ion beam instrument in Australia. Focused ion beam microscopes are rapidly evolving instruments that harness the properties of ions to remove unwanted material from specimens. Integration of a fluorescent optical microscope within the same instrument will allow the targeted imaging of bio/material interfaces, cell and protein structure in their native environment. The potential innovations, applications and benefits to society are far reaching, with the facility expected to impact the development of atomic-scale imaging of protein structures for future drug development, biological processes and materials for advanced technology and manufacturing