Conference: Steroid Action on Excitable Cells: November 6, 1993; Washington D.C.

提供资金用于支付青年科学家和应邀参加将于1993年11月6日在华盛顿特区举行的1993年神经科学学会关于类固醇作用于可兴奋细胞的会议的旅费。自20世纪60年代以来，人们已经很容易接受类固醇激素的作用机制是通过基因组途径。然而，在某些情况下，激素可以在几秒到几分钟内起作用。直到最近，这些数据都被忽略了，因为它不符合教条。现在已经很清楚，类固醇在大脑中的作用比以前认为的要复杂得多。事实上，类固醇的作用是由基因组和非基因组途径介导的。会议将讨论类固醇激素和甲状腺激素作用于可兴奋细胞的机制。报告将重点介绍令人兴奋的最新工作：(1)类固醇对海马体内氨基酸受体的调节作用；(2)使用简单的模型系统作为手段来检查激素对确定的、电压箝位的离子电流的作用；(3)新型激素受体；(4)类固醇的分子和生化作用。在一个快速发展和变化的领域，这些都是至关重要的问题。这次卫星研讨会提供了一个论坛，分享关于这一主题的想法，这可能最终导致在理解类固醇激素作用机制方面取得突破。

Funds are provided to defray travel costs of young scientists and invited participants to attend the Conference on Steroid Action on Excitable Cells which is to be held as a Satellite Symposium at the 1993 Society for Neuroscience on November 6, 1993 in Washington, DC. Since the 1960's, it has been readily accepted that the mechanism of steroid hormone action is by a genomic route. However, in some circumstances, hormones can have effects within seconds to minutes. Until recently, these data were ignored because it did not fit the dogma. Now it has become clear that steroid action in the brain is more complex than that previously thought. Indeed, steroid action is mediated by both genomic and non-genomic routes. The conference will address the mechanisms through which steroid hormones and thyroid hormones act on excitable cells. The presentations will highlight the exciting recent work on (1) the modulatory action of steroid on amino acid receptors in the hippocampus; (2) the use of simple model systems as means to examine the actions of hormones on identified, voltage-clamped, ion currents; (3) novel hormone receptors; and (4) the molecular and biochemical actions of steroids. These are fundamentally important questions in an field that is rapidly advancing and changing. This Satellite Symposium offers a forum for sharing of ideas on this subject which may ultimately lead to breakthroughs in understanding the mechanisms of steroid hormone action.