STEROID HORMONE SYNTHESIS/INACTIVATION AND ACTION IN TERMINAL LUNG DEVELOPMENT

类固醇激素的合成/失活及其在肺发育末期的作用

• 批准号: RGPIN-2016-05870
• 负责人: Tremblay, Yves
• 金额: $ 2.04万
• 依托单位: Université Laval
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=630580
• 关键词: STEROID; HORMONE; SYNTHESIS; INACTIVATION; ACTION

The goal of this study is to characterize the role of androgens in the development of 3D lung structure. Androgens are known as male sex steroids but they exist in the blood of both sexes, although at higher levels for males. We showed in a recent experiment that when the effect of androgens is blocked by administration of a pure antiandrogen (flutamide) to neonatal mice, the last step of lung development (alveolarization) is altered and an obvious defect in lung structure is observed. Surprisingly, our data indicate that flutamide had the same effect in both sexes, showing that androgens are essential for normal lung development of males

这项研究的目的是描述雄激素在三维肺结构发展中的作用。雄激素被称为男性类固醇，但它们存在于两性的血液中，尽管男性的水平更高。我们在最近的一项实验中表明，当给新生小鼠注射纯抗雄激素(氟他胺)来阻断雄激素的作用时，肺发育的最后一步(肺泡化)发生改变，并观察到明显的肺结构缺陷。令人惊讶的是，我们的数据显示，氟他胺在两性中的作用是相同的，表明雄激素对男性正常的肺部发育是必不可少的。