FASEB SRC on Molecular and Systems Integration of Genomic and Nongenomic Steroid Hormone Action.

 描述（由申请人提供）： 核激素受体对其配体迅速响应以触发独立于转录的信号级联。最近的发现揭示了核受体的非基因组和基因组响应之间的各种水平的串扰，例如，通过激活细胞质和/或质膜定位的核受体而动员的激酶级联，对基因组相关受体调节的转录程序产生直接和间接影响。这种串扰甚至已经显示出对细胞间类固醇激素作用具有影响并影响器官生理学。因此，这是核受体领域的一个黄金时期，正在考虑新的和创新的方法来检查快速，非基因组核受体信号传导与经典的全基因组行动之间的系统范围的串扰。这次会议的目的是把不同的科学家聚集在一起（初级、高级和受训人员），专业知识包括内分泌学、能量代谢、神经内分泌学、表观遗传学、环境内分泌干扰物、心血管功能、生殖、免疫学，神经生物学和癌症提出令人兴奋的新发现，揭示了系统的新见解，核激素受体在非基因组和基因组水平的广泛作用。本次会议的多样性将通过建立新的合作或实验方法来促进和激发创新思想，这些方法是通过接触许多模型系统和演讲者的挑衅性结果而产生的。非基因组或基因组类固醇激素信号传导领域的国家和国际领导人将展示他们最近未发表的工作，重点是这两种途径的细胞内或细胞间整合。此外，受训人员和初级调查员将有充分机会介绍其工作并与高级调查员会晤。总之，这次会议将刺激新的治疗方法的发展，以解决复杂的人类疾病，导致一个公认的家庭的可药用目标，核受体的失调。

 DESCRIPTION (provided by applicant): Nuclear hormone receptors respond rapidly to their ligands to trigger signaling cascades independent of transcription. More recent discoveries revealed various levels of cross-talk between nongenomic and genomic responses of nuclear receptors with, for example, kinase cascades mobilized by activation of cytoplasmic and/or plasma membrane localized nuclear receptors exerting direct and indirect effects on the transcriptional program regulated by genome-associated receptors. Such crosstalk has even been shown to have an impact on intercellular steroid hormone action and influence organ physiology. Therefore, this is a prime period in the nuclear receptor field to be considering new and innovative approaches to examine system-wide crosstalk between rapid, nongenomic nuclear receptor signaling with classical genome-wide action. The purpose of this conference is to bring together a diverse group of scientists (junior, senior and trainees) with expertise ranging from endocrinology, energy metabolism, neuroendocrinology, epigenetics, environmental endocrine disruptors, cardiovascular function, reproduction, immunology, neurobiology and cancer to present exciting new discoveries that uncover fresh insights into system-wide action of nuclear hormone receptors acting at nongenomic and genomic levels. The diversity of this conference will foster and stimulate innovative ideas through the establishment of new collaborations or experimental approaches generated by exposure to the many model systems and provocative results of the speakers. National and international leaders in the fields of nongenomic or genomic steroid hormone signaling will present their most recent, unpublished work that focuses on intracellular or intercellular integration of these two pathways. Furthermore ample opportunities will be given to trainees and junior investigators to present their work and meet with senior investigators. In summary, this conference will stimulate the development of new therapeutic approaches to tackle complex human diseases that result from dysregulation of a recognized family of druggable targets, the nuclear receptors.