FASEB SRC on Molecular and Systems Integration of Genomic and Nongenomic Steroid Hormone Action.

FASEB SRC 关于基因组和非基因组类固醇激素作用的分子和系统整合。

• 批准号: 8978714
• 负责人: Donald B DeFranco
• 金额: $ 0.8万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-15 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8978714
• 关键词: Advertising; Attention; Award; Biological Models; Cardiovascular Physiology; Cardiovascular system; Cell membrane; Cells; Cloning; Collaborations; Communities; Complex; Development; Disease; Endocrine; Endocrine Disruptors; Endocrine Physiology; Endocrinology; Energy Metabolism; Epigenetic Process; Estrogens; Exposure to; Family; Fostering; Funding; Genetic Transcription; Genome; Genomics; Gonadal Steroid Hormones; Grant; Homeostasis; Inflammation; International; Investigation; Ligands; Malignant Neoplasms; Mediating; Medical; Metabolism; Molecular; Neurobiology; Neuroendocrinology; Neurosecretory Systems; Nuclear Hormone Receptors; Nuclear Receptors; Obesity; Oral; Organ; Pathway interactions; Phosphotransferases; Physiological; Physiological Processes; Physiology; Principal Investigator; Receptor Signaling; Reproduction; Reproductive Immunology; Research; Research Personnel; Scientist; Senior Scientist; Signal Pathway; Signal Transduction; Societies; Steroids; System; Systems Integration; Translations; Travel; Underrepresented Minority; Woman; Work; abstracting; body system; driving force; environment related cancer; genome-wide; human disease; innovation; insight; meetings; member; non-genomic; novel; novel therapeutic intervention; posters; programs; public health relevance; receptor; response; steroid hormone; steroid hormone receptor; symposium; tumor metabolism; unpublished works

 DESCRIPTION (provided by applicant): Nuclear hormone receptors respond rapidly to their ligands to trigger signaling cascades independent of transcription. More recent discoveries revealed various levels of cross-talk between nongenomic and genomic responses of nuclear receptors with, for example, kinase cascades mobilized by activation of cytoplasmic and/or plasma membrane localized nuclear receptors exerting direct and indirect effects on the transcriptional program regulated by genome-associated receptors. Such crosstalk has even been shown to have an impact on intercellular steroid hormone action and influence organ physiology. Therefore, this is a prime period in the nuclear receptor field to be considering new and innovative approaches to examine system-wide crosstalk between rapid, nongenomic nuclear receptor signaling with classical genome-wide action. The purpose of this conference is to bring together a diverse group of scientists (junior, senior and trainees) with expertise ranging from endocrinology, energy metabolism, neuroendocrinology, epigenetics, environmental endocrine disruptors, cardiovascular function, reproduction, immunology, neurobiology and cancer to present exciting new discoveries that uncover fresh insights into system-wide action of nuclear hormone receptors acting at nongenomic and genomic levels. The diversity of this conference will foster and stimulate innovative ideas through the establishment of new collaborations or experimental approaches generated by exposure to the many model systems and provocative results of the speakers. National and international leaders in the fields of nongenomic or genomic steroid hormone signaling will present their most recent, unpublished work that focuses on intracellular or intercellular integration of these two pathways. Furthermore ample opportunities will be given to trainees and junior investigators to present their work and meet with senior investigators. In summary, this conference will stimulate the development of new therapeutic approaches to tackle complex human diseases that result from dysregulation of a recognized family of druggable targets, the nuclear receptors.

 描述（由申请人提供）： 核激素受体对其配体快速做出反应，触发独立于转录的信号级联反应。最近的发现揭示了核受体的非基因组和基因组反应之间存在不同程度的串扰，例如，通过激活细胞质和/或质膜定位的核受体而动员的激酶级联，对基因组相关受体调节的转录程序产生直接和间接的影响。这种串扰甚至已被证明对细胞间类固醇激素的作用和器官生理学有影响。因此，这是核受体领域考虑新的和创新的方法来检查快速非基因组核受体信号传导与经典全基因组作用之间的全系统串扰的黄金时期。本次会议的目的是汇集具有内分泌学、能量代谢、神经内分泌学、表观遗传学、环境内分泌干扰物、心血管功能、生殖、免疫学、神经生物学和癌症等专业知识的不同科学家群体（初级、高级和实习生），提出令人兴奋的新发现，揭示对核激素受体作用的全系统作用的新见解。 非基因组和基因组水平。本次会议的多样性将通过建立新的合作或实验方法来培育和激发创新思想，这些新的合作或实验方法是通过接触许多模型系统和演讲者的挑衅性结果而产生的。非基因组或基因组类固醇激素信号传导领域的国内和国际领导者将展示他们最新的、未发表的工作，重点关注这两种途径的细胞内或细胞间整合。此外，还将为实习生和初级研究人员提供充足的机会展示他们的工作并与高级研究人员会面。总之，本次会议将促进新治疗方法的开发，以解决因公认的可药物靶标家族（核受体）失调而引起的复杂人类疾病。