High Performance Imaging in Biological Research

Grand Challenge应用程序组竞赛提供 一个支持多学科小组的机制， 科学家和工程师，以实现高性能 1992财政年度计算机和通信（HPCC）倡议。 理想的建议不仅提供了卓越的科学： 重点问题，有可能在一个 科学和工程的关键领域），但也很重要 科学和计算活动之间的相互作用， 通常涉及数学、计算机或计算 科学家，这将对高性能 计算活动超出了特定的科学或 工程问题领域或正在研究的学科。 这是 一个研究和开发自动交互式 显微镜（AIM）。 AIM将结合联合收割机的最新技术， 光学显微镜和试剂化学与先进技术， 计算机化图像处理、图像分析和显示， 在高性能并行计算机上实现。 这 结合将产生一个自动化，高速，互动的工具， 这将使新的基础生物学研究成为可能， 活细胞和组织。 虽然研究的一个里程碑将 为了展示AIM的概念验证，正在进行的推力将是 随着新技术的出现， 生物界的。

The Grand Challenge Application Groups competition provides one mechanism for the support of multidiscipinary teams of scientists and engineers to meet the goals of the High Performance Computing and Communications (HPCC) Initiative in Fiscal Year 1992. The ideal proposal provided not only excellence in science: focussed problem with potential for substantial impact in a critical area of science and engineering) but also significant interactions between scientific and computational activities, usually involving mathematical, computer or computational scientists, that would have impact in high-performance computational activity beyond the specific scientific or engineering problem area(s) or discipline being studied. This is a project to research and develop an Automated Interactive Microscope (AIM). The AIM will combine the latest technologies in light microscopy and reagent chemistry with advanced techniques for computerized image processing, image analysis, and display, implemented on high-performance parallel computers. This combination will produce an automated, high-speed, interactive tool that will make possible new kinds of basic biological research on living cells and tissues. While one milestone of the research will be to show the proof-of-concept of AIM, the on-going thrust will be continued development as new technologies arise and the involvement of the biological community.