Advanced Multiscale Biological Imaging using European Infrastructures

先进的多尺度生物成像使用欧洲生物结构（AMBER）联盟已被组装用于开发和发展大规模的欧洲基础设施，以解决从分子到细胞，到组织，器官和生物体组织水平的长度尺度上的生物成像的关键需求。它汇集了包括临床医生、生物和生物医学科学家、物理科学家和设施/基础设施科学家在内的广泛能力，这一举措是在设施开发、数据管理、数据分析和解释等科学领域发生显著变化的时候提出的。很难想象有哪个时代比现在更需要以适应性和渐进的方式将不同领域的社区聚集在一起。鉴于体外生物医学研究与体内和离体结果相关的重要性，目前临床和基础科学之间的差距是一个巨大的挑战。AMBER联合体和该计划旨在弥合这些领域-在欧洲中央设施X射线和中子束源以及补充技术方面有大量技术和方法发展的时候。人工智能和机器学习方法的应用也出现了爆炸性增长和日益趋同。AMBER将以前所未有的方式汇集并实现医学，生物学和方法学能力，对欧洲的下一代研究和下一代研究人员产生深远的潜在影响。工作将包括技术开发，特别是在结合成像技术和数据方面，以提供疾病背景下生命过程的整体图像，以及具有挑战性的疾病相关样本和系统的成像，包括离体、体内样品和医疗技术对象、分析和建模。该计划将建立更紧密的联系，生物医学和临床社区之间，开放的研究基础设施，所产生的知识的新用户。它还将带来高水平的跨学科和多技术专业知识以及世界领先的基础设施能力，专注于对人类健康具有根本价值的问题。以下承诺的合作组织将带来独特的能力和能力：隆德高级中子和X射线科学研究所（LINXS）、隆德MAX IV实验室、隆德欧洲放射源（ESS）、劳厄-朗之万研究所（ILL）、莱斯特大学结构和化学生物学研究所、欧洲分子生物学实验室（EMBL）、以及波兰科学院的国际分子机制和机器研究所（IMOL）。

The Advanced Multiscale Biological Imaging using European Infrastructures (AMBER) consortium has been assembled for exploitation and development of large-scale European infrastructures to address key needs for biological imaging over length scales from molecular, through cellular, to tissue, organ and organism levels of organisation. It brings together a wide range of competence including clinical practitioners, biological and biomedical scientists, physical scientists, and facility/infrastructure scientists.This initiative is being made at a time when remarkable changes are occurring on the scientific landscape in terms of facility developments, data management, and data analysis and interpretation. It is hard to imagine a time for which there has been a bigger need to bring together communities from different fields in an adaptive and progressive way. The current gap between clinical and fundamental science is a great challenge given the importance of relating in vitro biomedical research with in vivo and ex vivo results. The AMBER consortium and the programme has been designed to bridge these fields - at a time in which there are massive technical and methodological developments in Europe at central facility X-ray and neutron beam sources, and complementary techniques. There is also explosive growth and increasing convergence in the application of artificial intelligence and machine learning approaches. AMBER will bring together and enable medical, biological, and methodological capabilities in an unprecedented way, with a profound potential impact for Europe's next generationresearch and next generation researchers.Work will include technique development, particularly in terms of combining imaging techniques and data to provide an overall picture of life processes in the context of disease, as well as imaging of challenging disease relevant samples and systems, including ex vivo, in vivo samples and medical technology objects, analysis and modelling. The programme will create closer ties to and between biomedical and clinical communities, opening the research infrastructures to new users of the knowledge generated. It will also bring high level interdisciplinary and multi-technique expertise alongside world-leading infrastructure capability to focus on problems of fundamental value to human health. The following committed partnering organisations will bring in unique competence and capability: The Lund Institute of Advanced Neutron and X-ray Science (LINXS), the MAX IV Laboratory, Lund, the European Spallation Source (ESS), Lund, the Institut Laue-Langevin (ILL), the Institute for Structural and Chemical Biology within the University of Leicester, the European Molecular Biology Laboratory (EMBL), and the International Institute of Molecular Mechanisms and Machines (IMOL), of the Polish Academy of Sciences.