Multiuser Fast NMR Field Cyc#lng Instrument

本项目提出建设一个强大的变场核磁共振（NMR）光谱仪（范围从0到2特斯拉），用于研究各种材料的弛豫和分子动力学，包括液晶、磷脂膜和聚合物。以及生物无机化合物中的键合结构。场循环核磁共振（FC-NMR）是一种创新的、相当新的技术，这种FC-NMR光谱仪还没有商用。FC-NMR光谱仪的主要应用将是在低到中等磁场强度（0到2特斯拉）下获得各种材料在固态和液晶状态下IH、2H、19f和31P核的弛豫特性的新信息，在这些地方使用标准的核磁共振方法很难或不可能测量。弛豫机制将产生关于待研究的各种材料中分子动力学的新信息。了解低磁场（低频）区域的弛豫对于全面理解固体、液晶和膜中的分子特性是必不可少的。FC-NMR谱仪还将用于获取生物无机物质中四极核（如2H、14N、17O和59Co）周围的电荷分布信息，这对于详细了解它们的反应化学及其在酶机制中的作用至关重要。

This project proposes the construction of a powerful, variable-field nuclear magnetic resonance (NMR) spectrometer (range from 0 to 2 Tesla) for the investigation of relaxation and molecular dynamics in a broad range of materials, including liquid crystals, phospholipid membranes, and polymers, as well as bonding structure in bioinorganic compounds. Field-cycling NMR (FC-NMR) is an innovative and rather new technique and such FC-NMR spectrometers are not commercially available. The major application of the FC-NMR spectrometer will be to obtain novel information on the relaxation properties of IH, 2H, l9F, and 31P nuclei in the solid and liquid-crystalline states of various materials at low to intermediate magnetic fields strengths (0 to 2 Tesla), where measurements using standard NMR methods are difficult or impossible. The relaxation mechanisms will yield new information regarding the dynamics of the molecules in the various materials to be studied. Knowledge of the relaxation in the low magnetic field (low frequency) region is essential to obtain any comprehensive understanding of the molecular properties in solids, liquid crystals, and membranes. The FC-NMR spectrometer will also be used to obtain information regarding the charge distribution around quadrupolar nuclei, such as 2H, 14N, 17O, and 59Co in bioinorganic substances, which is essential to achieve a detailed understanding of their reaction chemistry and their role in enzyme mechanisms.