Multiuser Fast NMR Field Cyc#lng Instrument

多用户快速 NMR 现场循环

• 批准号: 9217224
• 负责人: Constantin Job
• 金额: $ 11.89万
• 依托单位: University of Arizona
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-04-15 至 1996-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9217224&HistoricalAwards=false
• 关键词: Multiuser; Fast; NMR; Field; Cyc#lng

This project proposes the construction of a powerful, variable-field nuclear magnetic resonance (NMR) spectrometer (range from 0 to 2 Tesla) for the investigation of relaxation and molecular dynamics in a broad range of materials, including liquid crystals, phospholipid membranes, and polymers, as well as bonding structure in bioinorganic compounds. Field-cycling NMR (FC-NMR) is an innovative and rather new technique and such FC-NMR spectrometers are not commercially available. The major application of the FC-NMR spectrometer will be to obtain novel information on the relaxation properties of IH, 2H, l9F, and 31P nuclei in the solid and liquid-crystalline states of various materials at low to intermediate magnetic fields strengths (0 to 2 Tesla), where measurements using standard NMR methods are difficult or impossible. The relaxation mechanisms will yield new information regarding the dynamics of the molecules in the various materials to be studied. Knowledge of the relaxation in the low magnetic field (low frequency) region is essential to obtain any comprehensive understanding of the molecular properties in solids, liquid crystals, and membranes. The FC-NMR spectrometer will also be used to obtain information regarding the charge distribution around quadrupolar nuclei, such as 2H, 14N, 17O, and 59Co in bioinorganic substances, which is essential to achieve a detailed understanding of their reaction chemistry and their role in enzyme mechanisms.

该项目建议建造一个强大的可变场核磁共振(核磁共振)光谱仪(范围从0到2特斯拉)，用于研究各种材料的弛豫和分子动力学，包括液晶、磷脂膜和聚合物，以及生物无机化合物中的成键结构。场循环核磁共振(FC-核磁共振)是一种创新的、相当新的技术，这种FC-核磁共振光谱仪还没有商业化。FC-NMR谱仪的主要应用将是获得各种材料在低到中等磁场强度(0到2特斯拉)下固态和液晶态IH、2H、19F和31P核的弛豫特性的新信息，使用标准核磁共振方法进行测量是困难或不可能的。松弛机制将产生关于各种材料中分子动力学的新信息。了解低磁场(低频)区的驰豫对于全面了解固体、液晶和膜中的分子性质是必不可少的。FC-核磁共振光谱仪还将用于获得有关生物无机物质中2H、14N、17O和59Co等四极核周围电荷分布的信息，这对于详细了解它们的反应化学和它们在酶机制中的作用是必不可少的。