Long-Range Electron Transfer Reactions in Proteins

蛋白质中的长程电子转移反应

• 批准号: 9221603
• 负责人: Jorge Colón
• 金额: $ 3.2万
• 依托单位: University of Puerto Rico
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-09-01 至 1994-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9221603&HistoricalAwards=false
• 关键词: Long; Range; Electron; Transfer; Reactions

This award is the starter grant increment of Dr. Colon's Postdoctoral Fellowship in Chemistry. The research will result in a better understanding of the reorganizational energy of molecules as a function of distance in long range electron transfer reactions. Electron transfer rates will be measured for Re(II) and Re(I) coordinated to human myoglobin variants. The effects of distance of electron transfer and of the electronic coupling in the protein on electron transfer rates will be evaluated. Flash-quench and photoinduced electron transfer experiments will be used to obtain the desired rates. %%% Biological electron transfer plays major roles in respiration, photosynthesis, and immune response. The research to be carried out will provide a better insight into these important reactions. These insights will be helpful to scientists studying many aspcects of human health.

这个奖项是科隆博士的启动补助金增量 化学博士后奖学金。这项研究将导致 为了更好地理解 长程电子中分子距离的函数 转移反应 电子转移率将被测量 Re（II）和Re（I）与人肌红蛋白变体配位。 研究了电子转移距离和分子量对电子转移的影响。 蛋白质中的电子耦合对电子转移速率的影响 将被评估。闪光猝灭与光生电子 将使用转移实验来获得期望的速率。 %%% 生物电子传递在呼吸中起主要作用， 光合作用和免疫反应。要进行的研究 将提供更好的洞察这些重要的 反应.这些见解将对科学家有帮助 研究人类健康的许多方面。