Single-Molecule Studies of Cell Cycle Regulation: Microtubules as Enzyme Scaffolds in Mitosis

细胞周期调控的单分子研究：微管作为有丝分裂中的酶支架

• 批准号: 206005
• 负责人: Brouhard Gary J
• 金额: $ 7.29万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2009
• 资助国家: 加拿大
• 起止时间: 2009-10-01 至 2010-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=206005&lang=en
• 关键词: Aurora-B; Cell Cycle; Chromosome Passenger Complex; Kinase; Microtubule; Mitosis

Microtubules are long, slender filaments of the protein tubulin, with which the cell constructs the mitotic spindle, axonemes, and the microtubule cytoskeleton. Due to their stiffness and resistance to compressive load, microtubules act to stabilize cell

微管是蛋白质微管蛋白的细长细丝，细胞用其构建有丝分裂纺锤体，轴丝， 和微管细胞骨架。由于它们的刚度和抗压缩负荷，微管起到稳定细胞的作用，