Studies of Chemical Rates Processes by Means of Size and Charge Resolved 2D-NMR

在化学学部物理化学项目的支持下，北卡罗来纳大学教堂山分校的C. Johnson教授将在扩散有序二维核磁共振波谱领域进行研究。这项研究将致力于技术和仪器的发展，以及它们在化学交换效应、涉及表面活性剂和大分子的结合平衡、胶束和胶束烷等方面的应用。还将继续发展流动有序的二维核磁共振波谱，特别强调50至200纳米大小的囊泡的扩散和流动的电动研究和数据分析。在凝聚态介质的核磁共振谱中观察到的弛豫率受到分子在介质中进行平动和重定向运动时的大小和形状所决定的摩擦效应的影响。最近发展的扩散有序二维核磁共振波谱技术可以识别混合物的分子成分，并同时表征聚集体和其他结构的大小。利用这种技术的一种变化，流动有序二维核磁共振波谱，人们能够识别和确定离子在凝聚态介质中的流动。约翰逊教授的研究是为了改进这些方法，并将它们扩展到三维领域。

In this project, supported by the Physical Chemistry Program of the Chemistry Division, Prof. C. Johnson of the University of North Carolina at Chapel Hill will conduct research in the area of diffusion-ordered two-dimensional nuclear magnetic resonance spectroscopy. This research will be devoted to the development of techniques and instrumentation, and their applications to chemical exchange effects, binding equilibria involving surfactants and macromolecules, and micelles and micellanes. Work will also be done on the continued development of mobility-ordered two-dimensional nuclear magnetic resonance spectroscopy with special emphasis on electrokinetic studies and data analysis for the diffusion and mobility of vesicles ranging in size from 50 to 200 nanometers. %%% The relaxation rates observed in nuclear magnetic resonance spectra of condensed media are affected by frictional effects determined by the sizes and shapes of molecules as they undergo translational and reorientational motions in the medium. The recently developed technique of diffusion-ordered two-dimensional nuclear magnetic resonance spectroscopy allows the identification of molecular components of mixtures and the simultaneous characterization of the sizes of aggregates and other structures present. Using a variation of this technique, mobility-ordered two-dimensional nuclear magnetic resonance spectroscopy, one is able to identify and determine the mobilities of ions in condensed media. The research by Professor Johnson serves to improve on these methods and extend them into the three dimensional domain.