Grant for Exploratory Research: Very Large Magnetic Field Gradients for Diffusion Ordered NMR by Means of Sample Shuttling

探索性研究资助：通过样品穿梭实现扩散有序核磁共振的超大磁场梯度

• 批准号: 9318655
• 负责人: Charles Johnson
• 金额: $ 4.99万
• 依托单位: University of North Carolina at Chapel Hill
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-12-15 至 1995-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9318655&HistoricalAwards=false
• 关键词: Grant; Exploratory; Research; Very; Large

9318655 Johnson In this project of the Physical Chemistry Program of the Chemistry Division, Prof. C. S. Johnson of the University of North Carolina proposes to develop an improvement in current NMR technique to allow the study of ultra slow translational (diffusional) motions of molecules and molecular aggregates in condensed media. An existing standard commercial NMR spectrometer will be modified to allow the use of large magnetic field gradients and high resolution NMR in the same experiment. This project is exploratory in nature and is supported through a Small Grant for Exploratory Research (SGER). %%% The limitations of present methods of Nuclear Magnetic Resonance (NMR) spectroscopy make for difficulties in studying the transport of large micelles and vesicles, restricted diffusion in cells and porous solids, and the simultaneous measurement of diffusion rates of various size probe particles in tight gels and polymers. The exploratory research to be undertaken in this project seeks to overcome these limitations through the combination of several new techniques and adapting them for inclusion in a standard commercial spectrometer. The successful execution of this plan will bring about a major advance of the NMR technique and will have important consequences and great benefits to several applied areas, such as polymer chemistry, biochemistry, and the dynamics of glassy materials. ***

9318655约翰逊在这个项目的物理化学计划的化学部，教授C。S.北卡罗来纳州大学的约翰逊建议改进现有的核磁共振技术，以研究凝聚介质中分子和分子聚集体的超慢平移（扩散）运动。 现有的标准商用核磁共振波谱仪将被修改，以允许在同一实验中使用大磁场梯度和高分辨率核磁共振。 该项目是探索性的，并通过探索性研究（SGER）的小额赠款支持。 目前核磁共振（NMR）光谱方法的局限性使得难以研究大胶束和囊泡的运输，细胞和多孔固体中的受限扩散，以及同时测量各种尺寸探针颗粒在紧密凝胶和聚合物中的扩散速率。 本项目将进行的探索性研究旨在通过结合几种新技术并加以调整以纳入标准商用分光计来克服这些局限性。 该计划的成功实施将带来NMR技术的重大进步，并将对多个应用领域产生重要影响和巨大利益，如聚合物化学，生物化学和玻璃态材料的动力学。 ***