Grant for Exploratory Research: Very Large Magnetic Field Gradients for Diffusion Ordered NMR by Means of Sample Shuttling

9318655 Johnson北卡罗莱纳大学的C. S. Johnson教授在化学学部物理化学项目中提出了对现有核磁共振技术的改进，以研究分子和分子聚集体在凝聚介质中的超慢平移（扩散）运动。现有的标准商用核磁共振光谱仪将被修改，以允许在同一实验中使用大磁场梯度和高分辨率核磁共振。该项目是探索性的，并通过探索性研究小额赠款（SGER）得到支持。目前的核磁共振（NMR）光谱方法的局限性使得研究大胶束和囊泡的传输、细胞和多孔固体中的受限扩散以及同时测量不同大小的探针颗粒在紧密凝胶和聚合物中的扩散速率存在困难。在这个项目中进行的探索性研究试图通过几种新技术的结合来克服这些限制，并使它们适应于标准的商用光谱仪。该计划的成功实施将带来核磁共振技术的重大进步，并将对聚合物化学、生物化学和玻璃材料动力学等多个应用领域产生重要影响和巨大利益。＊＊＊

9318655 Johnson In this project of the Physical Chemistry Program of the Chemistry Division, Prof. C. S. Johnson of the University of North Carolina proposes to develop an improvement in current NMR technique to allow the study of ultra slow translational (diffusional) motions of molecules and molecular aggregates in condensed media. An existing standard commercial NMR spectrometer will be modified to allow the use of large magnetic field gradients and high resolution NMR in the same experiment. This project is exploratory in nature and is supported through a Small Grant for Exploratory Research (SGER). %%% The limitations of present methods of Nuclear Magnetic Resonance (NMR) spectroscopy make for difficulties in studying the transport of large micelles and vesicles, restricted diffusion in cells and porous solids, and the simultaneous measurement of diffusion rates of various size probe particles in tight gels and polymers. The exploratory research to be undertaken in this project seeks to overcome these limitations through the combination of several new techniques and adapting them for inclusion in a standard commercial spectrometer. The successful execution of this plan will bring about a major advance of the NMR technique and will have important consequences and great benefits to several applied areas, such as polymer chemistry, biochemistry, and the dynamics of glassy materials. ***