Synthetic Studies Related to Natural Products

天然产物相关的合成研究

• 批准号: 9223429
• 负责人: John Brauman
• 金额: $ 36.15万
• 依托单位: Stanford University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-02-01 至 1999-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9223429&HistoricalAwards=false
• 关键词: Synthetic; Studies; Related; Natural; Products

The focus of this research will involve the use of cation-stabilizing (C-S) auxiliaries to enhance the yield, stereo- and regioselectivity of polyene cyclization processes. The role of the auxiliaries will be explored by placing them at varied positions on the substrate, by developing new C-S functional groups, by studying the effect of using two or more C-S functions and by applying the concept to the synthesis of hitherto difficult to obtain polycyclics of biological importance. A second focus will involve the use of chiral acetals to induce asymmetric synthesis. %%% With this Accomplishment Based Renewal, the Synthetic Organic Program is supporting the research of Dr. William S. Johnson of the Department of Chemistry at Stanford university. Professor Johnson will focus his work on developing reactions that mimic, and even rival in efficiency, enzymatic ring-forming processes which form polycyclic carbon compounds of biological importance.

这项研究的重点将涉及使用阳离子稳定剂(C-S)来提高多烯环化过程的产率、立体选择性和区域选择性。通过将助剂放置在底物上的不同位置、开发新的C-S官能团、研究使用两个或多个C-S官能团的效果以及将这一概念应用于合成迄今难以获得的具有生物重要性的多环化合物，将探索助剂的作用。第二个重点将涉及使用手性缩醛来诱导不对称合成。通过这项基于成果的更新，合成有机计划正在支持斯坦福大学化学系的威廉·S·约翰逊博士的研究。约翰逊教授将专注于开发模拟、甚至在效率上与形成具有生物重要性的多环碳化合物的酶形成环过程相媲美的反应。