Synthetic Studies Related to Natural Products

这项研究的重点将涉及使用 阳离子稳定（C-S）助剂以提高产率， 多烯环化过程立体和区域选择性。 辅助人员的作用将通过将其放置在 通过开发新的C-S， 功能组，通过研究使用两个或更多个 C-S函数，并将其应用于 迄今难以获得生物多环化合物 重要性 第二个焦点将涉及手性的使用。 缩醛诱导不对称合成。 %%% 有了这种基于成就的更新，合成有机 该项目支持William S.约翰逊， 斯坦福大学化学系。 教授 约翰逊将把他的工作重点放在开发模仿， 在效率上甚至可以与之匹敌，酶促成环过程 它们形成生物的多环碳化合物， 重要性

The focus of this research will involve the use of cation-stabilizing (C-S) auxiliaries to enhance the yield, stereo- and regioselectivity of polyene cyclization processes. The role of the auxiliaries will be explored by placing them at varied positions on the substrate, by developing new C-S functional groups, by studying the effect of using two or more C-S functions and by applying the concept to the synthesis of hitherto difficult to obtain polycyclics of biological importance. A second focus will involve the use of chiral acetals to induce asymmetric synthesis. %%% With this Accomplishment Based Renewal, the Synthetic Organic Program is supporting the research of Dr. William S. Johnson of the Department of Chemistry at Stanford university. Professor Johnson will focus his work on developing reactions that mimic, and even rival in efficiency, enzymatic ring-forming processes which form polycyclic carbon compounds of biological importance.