Synthetic Studies Related to Natural Products

本研究的重点将涉及使用阳离子稳定（C-S）助剂来提高多烯环化过程的产率、立体选择性和区域选择性。通过将助剂放置在底物上的不同位置，通过开发新的C-S官能团，通过研究使用两个或多个C-S官能团的效果，以及通过将这一概念应用于迄今为止难以获得的具有生物学重要性的多环化合物的合成，将探索助剂的作用。第二个重点将涉及使用手性缩醛来诱导不对称合成。通过这种基于成就的更新，合成有机项目正在支持斯坦福大学化学系威廉·s·约翰逊博士的研究。约翰逊教授将把他的工作重点放在开发一种反应上，这种反应可以模仿酶促环形成过程，甚至在效率上与酶促环形成过程相媲美。酶促环形成过程可以形成具有生物重要性的多环碳化合物。

The focus of this research will involve the use of cation-stabilizing (C-S) auxiliaries to enhance the yield, stereo- and regioselectivity of polyene cyclization processes. The role of the auxiliaries will be explored by placing them at varied positions on the substrate, by developing new C-S functional groups, by studying the effect of using two or more C-S functions and by applying the concept to the synthesis of hitherto difficult to obtain polycyclics of biological importance. A second focus will involve the use of chiral acetals to induce asymmetric synthesis. %%% With this Accomplishment Based Renewal, the Synthetic Organic Program is supporting the research of Dr. William S. Johnson of the Department of Chemistry at Stanford university. Professor Johnson will focus his work on developing reactions that mimic, and even rival in efficiency, enzymatic ring-forming processes which form polycyclic carbon compounds of biological importance.