Studies on synthetic antioxidants for prevention of oxidative stress-related diseases

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The development of antioxidants with strong radical-scavenging activities has attracted considerable attention in recent years for preventing oxidative stress related diseases. We focused on the chemical modification of natural catechin to improve its pharmacological properties with the aim of developing clinically useful chemopreventive agents. Treatment of catechin with ketone by way of an Oxa-Pictet-Spengler reaction enabled the structure of catechin to be planar. Thus synthesized planar catechin analogues showed strong antioxidative activity. We also synthesized catechin analogues (CN) having nynhidrin structure. These catechin analogues significantly blocked the self-aggregation of s-amyloid and reduced the neuronal viability loss evoked by s-amyloid.